Results 71 to 80 of about 11,154,931 (355)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Sustaining women’s empowerment for development in resource-limited settings: an exploratory qualitative approach

Frontiers in Health Services
BackgroundWomen's empowerment is one of the fundamental issues for attaining sustainable development goals crossing multiple dimensions. In Ethiopia, Women’s Development Network (WDN), a network of women, was established in 2010 with development aims ...
Wanno Wallole, Abraham Alano, Misganu Endriyas   +2 more
doaj   +1 more source

Exploitation, transfer and rationalization of public assets

Techne, 2012
The paper traces the regulatory evolution of the processes of exploitation, transfer and rationalization of public assets, highlighting the different philosophies underlying the numerous regulatory interventions over the years, the first characterized by
Loredana Giani
doaj   +1 more source

Public Engagement, Knowledge Transfer, and Impact Validity

Journal of Social Issues, 2013
Public engagement and knowledge transfer are now necessary supplements to academic research and teaching activity for university‐based psychologists in the United Kingdom. However, a “deficit model” of public understanding is often assumed by national policies.
Hagger-Johnson, GE, Hegarty, P, Barker, M, Richards, C   +3 more
openaire   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

IP provisions of the EU-Central America Association Agreement and development issues [PDF]

, 2010
The recent Association Agreement signed between the European Union and Central American countries contains important intellectual property provisions.
Bonadio, Enrico
core   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The connection between public transfers and private interfamily transfers

Journal of Public Economics, 1995
Abstract This paper investigates the anti-poverty effectiveness of public transfers taking private-transfer responses into account. Widespread, altruistically motivated private transfers would neutralize the distributional impact of public transfers. But exchange-motivated transfers can reinforce the effects of public transfers on the distribution of
Donald Cox, George Jakubson
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The determinants of technology transfer efficiency and the role of innovation policies: a survey [PDF]

The diversity found in the various Technology Transfer Offices (TTOs), besides being a consequence of the capacities and motives of the different stakeholders involved (public research organisations, industry, consulting firms and public authorities ...
Aurora A.C. Teixeira, Maria D.M. Oliveira   +1 more
core