Results 61 to 70 of about 13,234,257 (284)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Determining the Public Health Impact of Climate Change: A National Study Using a Health Impact Assessment Approach in Wales

International Journal of Public Health
Objective: Climate change is recognised as the biggest threat to global health of the 21st century and impacts on health and wellbeing through a range of factors. Due to this, the need to take action in order to protect population health and wellbeing is
Liz Green, Kathryn Ashton, Nerys Edmonds, Michael Fletcher, Sumina Azam, Karen Hughes, Phil Wheater, Mark A. Bellis   +7 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Trust in Scientists and Food Manufacturers: Implications for the Public Support of Biotechnology [PDF]

An analysis of data from the U.S. Biotechnology Study, 1997S1998 reveals that few variables affect public trust in scientists, while variables representing perceived benefits, risks, trustworthiness, and competence affect trust in food manufacturers on ...
James, Harvey S., Jr.
core  

Public Values and Public Trust: Responses to Welfare State Reform in the UK [PDF]

, 2009
The current reform programme in the UK welfare state appears to improve cost-efficiency and responsiveness in many areas, but runs the risk of generating further problems.
Taylor-Gooby, Peter, PETER TAYLOR-GOOBY, ANDREW WALLACE, Wallace, Andrew   +3 more
core   +1 more source

Public satisfaction and trust towards the health system in China and associated factors: a mixed-methods study

BMC Public Health
Background Public’s perceptions of the health system provide valuable insights into its performance and inform future directions for improvement. This research aims to evaluate changes in public satisfaction and trust towards China’s health system from ...
Yanming Lin, Guoting Zhang, Hongqiao Fu
doaj   +1 more source

A Systematic Framework for Analyze Variables That Effect on Political Trust [PDF]

مطالعات مدیریت بهبود و تحول, 2012
Many researches name accountability and efficiency of the government as the main reasons for public trust. There are many evidences show that increase in resources and responsibilities of public sector is not match to the degree of accountability in this
Shamsosaadaat Zahedi, Mohammad Khanbashi
doaj