Results 91 to 100 of about 92,418,164 (308)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Modelos de Capital Intelectual y sus indicadores en la universidad pública Models of intellectual capital and indicators in the public university

Cuadernos de Administración, 2010
En el marco de la gestión del conocimiento se encuentra inmerso un aspecto de alta relevancia, no solo contable, sino también productivo y competitivo, el cual es denominado hoy día Capital Intelectual (C.I, se identificara con esta abreviatura).
José J. González Millán, Miryam T. Rodríguez Díaz   +1 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

“The South is My Country”: White Supremacy in Graduate Business Programs in Santa Catarina

RAC: Revista de Administração Contemporânea
Objective: this study aims to identify and analyze the factors contributing to the perpetuation of white supremacy in graduate business programs in the state of Santa Catarina, Brazil.
Karina Francine Marcelino, Cíntia Cristina Silva de Araújo, Mário César Barreto Moraes, Jair Nascimento Santos   +3 more
doaj   +1 more source

The University and the Prince: Public Funds Shaping University Trajectories

Italian Economic Journal
Abstract We develop an evolutionary model to analyse the role of policymaker’s preferences on the amount and direction of funding in determining university trajectories. Results are four. First, the policies that maximise performance in certain dimensions do not require that funds targeted at those dimensions are ...
Borsato, Andrea, Erasmo, Valentina, Lorentz, André   +2 more
openaire   +4 more sources

Catalog: Boston University School of Public Health [PDF]

, 1997
Viewbook/course catalog of the Boston University School of Public ...
Boston University School of Public Health
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Universities, conflict and the public sphere: trajectories of the public university in Lebanon

, 2021
Rarely examined through the prism of political theory, the public and private dimensions of universities tend to be defined in economistic terms of ‘who pays’ or ‘who benefits’, overlooking the political meanings of ‘public’ that relate to state-society relations and conditions of democracy.
openaire