Results 171 to 180 of about 1,664,402 (304)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Publication activity of organizations in Moscow region on nanotechnologies and nanosystems: bibliometric analysis

, 2012
This publication represents bibliometric analysis of publication activity of scientists from research institutions Moscow region in the field of ...
T. N. Kharybina, J. V. Mohknaveva
core  

Publication Activity and Impact of the International Pediatric Simulation Society Cureus Channel: 2014 to 2018. [PDF]

Cureus, 2019
Sawyer T, Rovera EJ.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

International publication activity in orthopaedic surgery over a ten-year interval. [PDF]

Eur J Trauma Emerg Surg
Michels C, Frosch KH, Beil FT, Debus ES, Grundmann RT.   +4 more
europepmc   +1 more source

Letter to the Editor: Publication Activity of Scientific Authors. [PDF]

J Korean Med Sci, 2016
Joob B, Wiwanitkit V.
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

The Development of the Method of Ratings Formation of Scientific and Scientific-pedagogical Staff Publication Activity

, 2017
The analysis of the publication activity of domestic universities according to SciVerse Scopus scientometric database is conducted and its dependence on the effectiveness of the motivation systems in these universities is established.
Zhuk, L. (Liliya), Kuzmin, O. (Oleh)
core  

Worldwide research productivity in fracture surgery: A 10-year survey of publication activity. [PDF]

Exp Ther Med, 2017
Sun J, Ding R, Ma T, Shi X, Bao C, Guan H.   +5 more
europepmc   +1 more source