Results 71 to 80 of about 3,279,698 (336)

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Dissemination and outcome reporting bias in clinical malaria intervention trials: a cross-sectional analysis

Malaria Journal
Background Dissemination and outcome reporting biases are a significant problem in clinical research, with far-reaching implications for both scientific understanding and clinical decision-making.
Lydia Pool, Claire Ruiz del Portal Luyten, Rob W. van der Pluijm, Patrick Soentjens, Thomas Hanscheid, Martin P. Grobusch, Benjamin J. Visser   +6 more
doaj   +1 more source

Meta-analyses in psychology often overestimate evidence for and size of effects

Royal Society Open Science, 2023
Adjusting for publication bias is essential when drawing meta-analytic inferences. However, most methods that adjust for publication bias do not perform well across a range of research conditions, such as the degree of heterogeneity in effect sizes ...
František Bartoš, Maximilian Maier, David R. Shanks, T. D. Stanley, Martina Sladekova, Eric-Jan Wagenmakers   +5 more
doaj   +1 more source

Copas' method is sensitive to different mechanisms of publication bias [PDF]

arXiv, 2020
Copas' method corrects a pooled estimate from an aggregated data meta-analysis for publication bias. Its performance has been studied for one particular mechanism of publication bias. We show through simulations that Copas' method is not robust against other realistic mechanisms.
arxiv  

MVPBT: R package for publication bias tests in meta-analysis of diagnostic accuracy studies [PDF]

arXiv, 2022
Meta-analysis for diagnostic test accuracy (DTA) has been a standard research method for synthesizing evidence from diagnostic studies. In DTA meta-analysis, although publication bias is an important source of bias, no certain methods similar to the Egger test in univariate meta-analysis have been developed to detect such bias.
arxiv  

Publication bias begins at home [PDF]

Emergency Medicine Journal, 2019
A few times a year, I have the opportunity to speak to emergency medicine clinicians about how to get their research published. Somewhere during the session, I’ll usually ask how many people have done research, and presented it at a scientific meeting—and the majority of hands go up.
openaire   +4 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Capture-recapture method for assessing publication bias

Journal of Research in Medical Sciences, 2010
<p style="line-height: 200%; margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong><span style="color: black;">Background</span></strong><span style="color ...
Jalal Poorolajal, AliAkbar Haghdoost, Mahmood Mahmoodi, Reza Majdzadeh, Siavosh Nasseri-Moghaddam, Akbar Fotouhi   +5 more
doaj   +2 more sources

Publication bias in clinical research

The Lancet, 1991
In a retrospective survey, 487 research projects approved by the Central Oxford Research Ethics Committee between 1984 and 1987, were studied for evidence of publication bias. As of May, 1990, 285 of the studies had been analysed by the investigators, and 52% of these had been published.
Easterbrook, P, Berlin, J, Gopalan, R, Matthews, D   +3 more
openaire   +3 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source