Results 161 to 170 of about 15,676,542 (289)

Microbial Source Tracking and the TMDL (Total Maximum Daily Loads) Process

open access: yes, 2014
This publication explains microbial source tracking (MST), also known as bacterial source tracking (BST), and four approaches to identifying sources of fecal pollution. It describes the specific methods used in Virginia's Total Maximum Daily Load program,
Hagedorn, Charles III   +2 more
core  

Publication process involving the discovery of artemisinin (qinghaosu) before 1985

open access: yesAsian Pacific Journal of Tropical Biomedicine, 2016
Man-Yuan Wang
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Deposit of microbial strains in public service collections as part of the publication process to underpin good practice in science. [PDF]

open access: yesSpringerplus, 2014
Stackebrandt E   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

The Academic Review Process: How Can We Make it More Efficient? [PDF]

open access: yes
Recently many editors try to reduce the turnaround times of academic journals. Shorter turnaround times, however, will induce many additional submissions of low-quality papers, increasing significantly the workload of editors and referees, and the number
Ofer H. Azar
core  

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