Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
From authorisation to clinical practice: evolution of the use of biological medicines according to the SmPC and guidelines (2006 to 2025). [PDF]
Eur J Clin PharmacolPenninx BMF +5 more
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Global Research Trends and Knowledge Structure in Autoimmune Gastritis and <i>Helicobacter pylori</i>: A Comprehensive Bibliometric Analysis (1991-2025). [PDF]
J Inflamm ResWu Y, Zhou J, Fang Y, Sang J, Zhang F.
europepmc +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Retraction: Application of Intelligent Computer-Assisted Taylor 3D External Fixation in the Treatment of Tibiofibular Fracture: Retrospective Case Study. [PDF]
JMIR Med InformJMIR Publications Editorial Office.
europepmc +1 more source
Retraction: Medical Data Feature Learning Based on Probability and Depth Learning Mining: Model Development and Validation. [PDF]
JMIR Med InformJMIR Publications Editorial Office.
europepmc +1 more source
Retraction: Medical Emergency Resource Allocation Model in Large-Scale Emergencies Based on Artificial Intelligence: Algorithm Development. [PDF]
JMIR Med InformJMIR Publications Editorial Office.
europepmc +1 more source
Retraction: Treatment of Left Ventricular Circulation Disorder: Application of Echocardiography Information Data Monitoring. [PDF]
JMIR Med InformJMIR Publications Editorial Office.
europepmc +1 more source