Results 131 to 140 of about 1,640,422 (231)
Orbital - Vol. 3 No. 3 - July-September 2011
Orbital: The Electronic Journal of Chemistry, 2011 Orbital Production
doaj
Orbital - Vol. 2 No. 3 - July-September 2010
Orbital: The Electronic Journal of Chemistry, 2011 Orbital Production
doaj
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Orbital - Vol. 2 No. 1 - January-March 2010
Orbital: The Electronic Journal of Chemistry, 2010 Orbital Production
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Orbital - Vol. 4 No. 1 - January-March 2012
Orbital: The Electronic Journal of Chemistry, 2012 Orbital Production
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Orbital - Vol. 4 No. 2 - April-June 2012
Orbital: The Electronic Journal of Chemistry, 2012 Orbital Production
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Orbital - Vol. 6 No. 3 - July-September 2014
Orbital: The Electronic Journal of Chemistry, 2014 Orbital Production
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