Results 161 to 170 of about 1,633,229 (254)
Orbital - Vol. 2 No. Suppl. 1 - MARCH 2010
Orbital: The Electronic Journal of Chemistry, 2010 Orbital Production
doaj
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Orbital - Vol. 3 No. 1 - January-March 2011
Orbital: The Electronic Journal of Chemistry, 2011 Orbital Production
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Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Orbital - Vol. 4 No. Suppl. 1 - APRIL 2012
Orbital: The Electronic Journal of Chemistry, 2012 Orbital Production
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Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Orbital - Vol. 5 No. 3 - July-September - Special Issue 2013
Orbital: The Electronic Journal of Chemistry, 2013 Orbital Production
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Orbital - Vol. 5 No. 4 - October-December 2013
Orbital: The Electronic Journal of Chemistry, 2014 Orbital Production
doaj
Erratum for previously published articles
Journal of King Saud University: Engineering Sciences, 2021 doaj +1 more source