Results 71 to 80 of about 1,437,784 (238)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

GIS-Publisher: Simplifying web-based GIS application development for enhanced data dissemination

SoftwareX
Geographic Information Systems (GIS) are complex systems that store, organize, process, and present geographically referenced data. Developing GIS requires specialized knowledge of algorithms, data structures, and geospatial concepts, along with the ...
Victor Lamas, David de Castro, Alejandro Cortiñas, Miguel R. Luaces   +3 more
doaj   +1 more source

Review of Online Evidence-based Practice Point-of-Care Information Summary Providers: Authors’ Reply to the Response by the Publisher of DynaMed

Journal of Medical Internet Research, 2010
We are pleased that the publisher of DynaMed clarified his evidence-based methodology in response to our review. We stress again how good reporting is a prerequisite for transparency.
Banzi, Rita, Liberati, Alessandro, Moschetti, Ivan, Tagliabue, Ludovica, Moja, Lorenzo   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Costs and Benefits of Animal Experiments: An Evaluation with Bias. By Andrew Knight. Palgrave Macmillan: Basingstoke, Hampshire, UK, 2011; Hardcover, 272 pp; ISBN 978-0-230-57686-5; Paperback, ISBN: 978-0-230-57687-2

Animals, 2012
The book is part of the Palgrave Macmillan Animal Ethics Series which was developed with the publisher and the Oxford Centre for Animal Ethics. Andrew Knight is a Fellow of the latter. The Centre “aims to demonstrate rigorous intellectual enquiry and the
Susanne Prankel
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gettysburg: Our College\u27s Magazine Spring 2014

, 2014
Table of Contents: Agriculture the Aperture, Global the View (Rebecca Croog, \u2714) What Is Your Passion? Professor Hakim Mohandas Amani Williams What Makes A Great... Zoo?
Communications & Marketing,
core   +1 more source