Results 71 to 80 of about 19,055,369 (244)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Science Communication in Electronic Journals in the Field of Traffic and Transport
Promet (Zagreb), 2005 Electronic journals have become an inevitable source ofscientific information. Their advantage, in relation to theprinted journals results from the characteristics of the media:they are available to all the interested users at the same time, beforethan ...
Mira Bačić +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
GIS-Publisher: Simplifying web-based GIS application development for enhanced data dissemination
SoftwareXGeographic Information Systems (GIS) are complex systems that store, organize, process, and present geographically referenced data. Developing GIS requires specialized knowledge of algorithms, data structures, and geospatial concepts, along with the ...
Victor Lamas +3 more
doaj +1 more source
Privacy for Electronic Information
, 2005 Information ...
Office of the Vice President for Information Technology
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Journal of Medical Internet Research, 2010 We are pleased that the publisher of DynaMed clarified his evidence-based methodology in response to our review. We stress again how good reporting is a prerequisite for transparency.
Banzi, Rita +4 more
doaj +1 more source