Results 61 to 70 of about 2,004,567 (296)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Publishing New Media in Higher Education: Overcoming the Adoption Hurdle

open access: yesJournal of Interactive Media in Education, 1998
The adoption process is the major means by which publishers get new learning materials into the hands of students in the higher education marketplace. In order for a new learning tool, be it print, multimedia, or other, to be adopted, an instructor must
Leslie G. Bondaryk
doaj   +1 more source

Publish, but don’t perish to publish [PDF]

open access: yesNature Human Behaviour, 2019
Each route to graduation is an individual journey. Friedrich M. Gotz, a PhD student in Psychology, argues that there are no ready-made recipes or silver bullets for success. While publications are important, the stress of producing them should not overshadow the joys of the journey.
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Letter to Sonora Dodd from the Evande Company, Publishers, April 4, 1911

open access: yes, 1911
Letter to Sonora Dodd from the Evande Company, Publishers, Utica, New York.https://digitalcommons.whitworth.edu/fathers-day-correspondence/1008/thumbnail ...
The Evande Company, Publishers,
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The feasibility and methods of developing the foreign language teachers’ competence in the field of using digital technologies in professional activities

open access: yesRUDN Journal of Informatization in Education
Problem statement. Every year, there are more and more studies aimed at improving the quality of digital resources created and used in the field of education, as well as at developing appropriate professional qualities among teachers.
Vadim V. Grinshkun, Victoria V. Kopylova
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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