Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications
British Journal of Clinical Pharmacology, EarlyView.Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba +2 more
wiley +1 more source
Comparative evaluation of artificial intelligence-assisted literature search tools for identifying clinically meaningful evidence in cardiology. [PDF]
Eur Heart J Digit HealthDi Febo R +8 more
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed +7 more
wiley +1 more source
Influenza vaccine uptake among healthcare workers in GCC countries: a narrative review of enablers and barriers. [PDF]
Front Public HealthAli SA +4 more
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley +1 more source
Comparative Efficacy of Interleukin Inhibitors and JAK Inhibitors in Moderate to Severe Plaque Psoriasis. [PDF]
CureusDaily A +4 more
europepmc +1 more source
Translational development of crisugabalin for neuropathic pain
British Journal of Clinical Pharmacology, EarlyView.Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João +5 more
wiley +1 more source
Correction: Developing an Artificial Intelligence Model for Reading Chest X-rays: Protocol for a Prospective Validation Study. [PDF]
JMIR Res ProtocJMIR Publications Editorial Office.
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Beta‐adrenoreceptor blockers (beta‐blockers) and selective serotonin reuptake inhibitors (SSRIs) are commonly used medications and often used together, such as for the treatment of anxiety. However, there is no recent review of any potential adverse events related to concomitant use of medicines from each group.
Ziyi Cai +10 more
wiley +1 more source
Correction: Attitudes Toward Digital Planetary Health Before and After a Lecture Series on Environmental Awareness and Future Visions: Repeated Cross-Sectional Survey Study Regarding Twin Transformation. [PDF]
JMIR Med EducNitsche J +4 more
europepmc +1 more source