Results 31 to 40 of about 673 (115)

Therapy With Local Anesthetics to Treat Vulvodynia. A Pilot Study

Sexual Medicine, 2022
: Introduction: Vulvodynia (chronic vulvar pain) is a sexually debilitating disorder with a prevalence of ∼10%. Aim: To investigate the effectiveness of therapy with local anesthetics (TLA) in women with severe vulvodynia, we conducted a prospective ...
Stefan Weinschenk, MD, Justus Benrath, MD, PhD, Eugen Kessler, MD, Thomas Strowitzki, MD, PhD, Manuel Feisst, MSc   +4 more
doaj   +1 more source

Chronic Scrotal Content Pain: A Practical Guide to Diagnosis and Management

Trends in Urology &Men's Health, Volume 17, Issue 6, December 2026.
ABSTRACT Chronic scrotal content pain (CSCP) is a common but often poorly understood condition that presents a significant diagnostic and therapeutic challenge. The broad differential diagnosis and frequent absence of an identifiable cause can lead to repeated investigations, delayed treatment and unnecessary surgery.
Mahin Chowdhury, Mohammad Arabiyat, Ibrahim Abuelbeh, Theodora Stasinou, Peter Grice, Vaibhav Modgil, Ian Pearce   +6 more
wiley   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, Volume 53, Issue 8, Page 1550-1561, August 2026.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Laparoscopic approach to refractory extraspinal sciatica and pudendal pain caused by intrapelvic nerve entrapment

Scientific Reports, 2021
Entrapments of the intrapelvic portions of the lumbosacral plexus are an important extraspinal cause of sciatica and pudendal neuralgia. They can be treated using Laparoscopic Neuronavigation (LANN), a minimally invasive technique that has set the ...
Nucelio Lemos, Corey Sermer, Gustavo Fernandes, Augusta Morgado-Ribeiro, Andrea Rossos, Zi Ying Zhao, Manuel J. B. C. Girão, Philip Peng   +7 more
doaj   +1 more source

Chronic idiopathic urinary retention and Fowler's syndrome in women: A multidisciplinary framework for assessment and nonsurgical management

BJUI Compass, Volume 7, Issue 7, July 2026.
Abstract Chronic idiopathic urinary retention and Fowler's syndrome are a debilitating problem primarily affecting women, characterised by an inability to urinate in the absence of any identifiable structural or other cause. An increasingly wide range of multifactorial predisposing, precipitating, and perpetuating biopsychosocial factors are being ...
Sarah McRae, Caoimhe McLoughlin, Carolyn Davie, Claire Hentzen, Dani Coombe, Claire Todd, Clare Nicholson, Beatrice Garcin, Glenn Nielsen, Helen Simpson, Laura McWhirter, Helen Jinadu, Jalesh Panicker, Anne Sanderson, Alan Carson, Martine Cornillet, Miriam Gamble, Voula Granitsiosis, Sioned Hancock, Collete Haslam, Leila Heelas, Victoria Hulman, Emily Jay, Mahreen Pakzad, Caroline Selai, Natalia Vasquez, Louise Young, Jon Stone, Ingrid Hoeritzauer   +28 more
wiley   +1 more source

Pudendal Nerve Neurolysis in Patients Afflicted With Pudendal Nerve Entrapment: A Systematic Review of Surgical Techniques and Their Efficacy [PDF]

International Neurourology Journal
To assess the effectiveness and safety of various techniques of pudendal nerve neurolysis (PNN) in patients with pudendal nerve entrapment (PNE).
Carlo Giulioni, Giacomo Maria Pirola, Martina Maggi, Lucia Pitoni, Demetra Fuligni, Mattia Beltrami, Vanessa Palantrani, Virgilio De Stefano, Valentina Maurizi, Daniele Castellani, Andrea Benedetto Galosi   +10 more
doaj   +1 more source

Phenol Neurolysis in Pain and Palliative Medicine

Pain Practice, Volume 26, Issue 5, June 2026.
ABSTRACT Background Pain is a common symptom in palliative care and affects patients' quality of life considerably. Standard analgesics are sometimes insufficient and are associated with substantial side effects. Neurolysis, the targeted destruction of nerves using thermal or chemical agents, offers an additional option for managing localized pain in ...
Jeroen H. A. Creemers, Rachel J. H. Smits, Alopi M. Patel, Robert T. M. van Dongen, Cornelis K. Kramers, Jacqueline M. Bos, Selina E. I. van der Wal   +6 more
wiley   +1 more source

Pudendal nerve neurolysis outcomes for urogenital and rectal disorders in patients suffering from pudendal nerve entrapment: A systematic review [PDF]

Investigative and Clinical Urology
Purpose: Pudendal neuropathy is an uncommon condition that exhibits several symptoms depending on the site of nerve entrapment. This study aims to evaluate the efficacy of pudendal nerve neurolysis (PNN) in improving lower urinary tract symptoms, anal ...
Carlo Giulioni, Lucia Pitoni, Demetra Fuligni, Mattia Beltrami, Valeria Passarella, Vanessa Palantrani, Virgilio De Stefano, Daniele Castellani, Andrea Benedetto Galosi   +8 more
doaj   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Adjusted Indirect and Mixed Comparisons of Drug Therapy for Neuropathic Cancer Pain

Pain Research and Management, Volume 2026, Issue 1, 2026.
Objectives Treatments for neuropathic cancer pain (NCP) are often based on guidelines or treatment data for neuropathic pain of noncancer origin. Therefore, their relative efficacy and safety are not well characterized and should be determined. This study aimed to compare the efficacy and safety of various pharmacological interventions for NCP ...
Ping Huang, Tingting Nan, Ruping Ni, Yuhong Huang, Maobai Liu, Jing Yang, Rita Chiaramonte   +6 more
wiley   +1 more source