Results 1 to 10 of about 93,759 (165)

Spontaneous regression of metastatic squamous cell lung cancer

open access: yesClinical Case Reports, 2018
Key Clinical Message Spontaneous regression (SR) of cancer is a rare but confirmed spectacular phenomenon, and it is even rarer in the context of advanced NSCLC. It is essential to understand this phenomenon in order to elucidate the nature of neoplastic
Miguel Ariza‐Prota   +2 more
doaj   +2 more sources

International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 8, Page 740-777, August 2023., 2023
Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well established to display time‐dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug ...
Lisa T. Hong   +16 more
wiley   +1 more source

Using random forest machine learning on data from a large, representative cohort of the general population improves clinical spirometry references

open access: yesThe Clinical Respiratory Journal, Volume 17, Issue 8, Page 819-828, August 2023., 2023
Abstract Introduction Spirometry is associated with several diagnostic difficulties, and as a result, misdiagnosis of chronic obstructive pulmonary disease (COPD) occurs. This study aims to investigate how random forest (RF) can be used to improve the existing clinical FVC and FEV1 reference values in a large and representative cohort of the general ...
Kris Kristensen   +7 more
wiley   +1 more source

Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors

open access: yesFrontiers in Oncology, 2020
Vasculogenic mimicry (VM) is a mechanism whereby cancer cells form microvascular structures similar to three-dimensional channels to provide nutrients and oxygen to tumors.
Olga N. Hernández de la Cruz   +7 more
doaj   +1 more source

Dietary phosphate restriction prevents the appearance of sarcopenia signs in old mice

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 14, Issue 2, Page 1060-1074, April 2023., 2023
Abstract Background Sarcopenia is defined by the progressive and generalized loss of muscle mass and function associated with aging. We have previously proposed that aging‐related hyperphosphataemia is linked with the appearance of sarcopenia signs. Because there are not effective treatments to prevent sarcopenia, except for resistance exercise, we ...
Elena Alcalde‐Estévez   +8 more
wiley   +1 more source

Metallodrugs: an approach against invasion and metastasis in cancer treatment

open access: yesFEBS Open Bio, Volume 12, Issue 5, Page 880-899, May 2022., 2022
In this review, we examine the use of metallodrugs for cancer treatment, focussing on the advances in this type of therapy and the importance of these compounds, with emphasis on Pt, Ru, Au, Zn, and Cu as antimetastatic agents. In addition, we discuss the different mechanisms of action by which metallodrugs exert their therapeutic effects.
Mauricio M. González‐Ballesteros   +2 more
wiley   +1 more source

Fetal movements: the origin of human behaviour

open access: yesDevelopmental Medicine &Child Neurology, Volume 63, Issue 10, Page 1142-1148, October 2021., 2021
The study of the onset and ontogeny of human behaviour has made it clear that a multitude of fetal movement patterns are spontaneously generated, and that there is a close association between activity and the development of peripheral and central structures.
Christa Einspieler   +2 more
wiley   +1 more source

Advancing science and education through a novel collaboration platform between the University of Michigan and Peking University Health Science Center

open access: yesFASEB BioAdvances, Volume 3, Issue 6, Page 428-438, June 2021., 2021
Abstract Research in China has been advancing over the past decade with increasing investments from government and private entities. Collaboration with Chinese investigators and those in the United States has also increased as reflected in the growth of scientific papers with Chinese authors. Collaborations are more commonly based on faculty‐to‐faculty
Joseph C. Kolars, Qimin Zhan
wiley   +1 more source

EL REGULADOR DE TRASMEMBRANA DE FIBROSIS QUÍSTICA (CFTR) DISFUNCIONAL Y SUS EFECTOS EXTRAPULMONARES

open access: yesNeumología Pediátrica, 2023
El daño del regulador de transmembrana de fibrosis quística (CFTR) puede causar una enfermedad grave fuera de los pulmones. El canal de cloruro (Cl-) ha sido el más estudiado, sin embargo, el bicarbonato (HCO3 -) tiene un rol muy importante en el ...
María Lina Boza
doaj   +1 more source

Leiomioma pulmonar primario

open access: yesRevista Colombiana de Cirugía, 2020
El leiomioma primario de pulmón es un tumor benigno raro, de origen mesodérmico, que representa aproximadamente el 2 % de todos los tumores benignos de pulmón. Desde que fue descrito por primera vez por Forkel en 1910, se han reportado al menos 150 casos
Ricardo Adolfo Zapata-González   +3 more
doaj   +1 more source

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