Results 121 to 130 of about 61,025 (285)

Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis [PDF]

, 2017
Change from baseline in swollen (a) and tender (b) joint counts. *Error bars show upper SE for placebo and lower SE for namilumab. SE standard error, SJC swollen joint count, TJC tender joint count.
A. Batalov, AD Cook, AD Cook, AD Cook, AE Nieuwenhuijze van, AJ Fleetwood, AK Ulfgren, AM Gestel van, B. Souberbielle, BC Trapnell, BC Trapnell, BP Hazenberg, C Fiehn, C Plater-Zyberk, CQ Chu, D. Saurigny, DL Scott, E. Esfandiari, E. Lloyd, EGE Vries de, EM Krinner, F Behrens, GR Burmester, GR Burmester, GR Burmester, GR Burmester, GS Firestein, IK Campbell, JA Hamilton, JA Hamilton, JA Hamilton, JC Gasson, JD Griffin, JM Alvaro-Gracia, M Hashimoto, ML Hetland, NJ Zvaifler, R. Stoilov, S Garcia, SA Antoniu, T Kitamura, T Takeuchi, T. W. J. Huizinga, T. Wagner, VA Manivel, W Kievit, W Wang, WD Xu   +47 more
core   +3 more sources

Diagnostic Dilemma in a Case of Anti‐PL‐7 Antibody‐Positive Interstitial Lung Disease: When Autoimmune Alveolar Proteinosis Masquerades as Anti‐Synthetase Syndrome

Respirology Case Reports, Volume 13, Issue 6, June 2025.
Pulmonary alveolar proteinosis (PAP) and anti‐PL‐7 antibody‐positive interstitial lung disease (ILD) share early radiographic similarities, yet their treatments differ significantly. This article reports a rare case of dual anti‐PL‐7 and anti‐GM‐CSF autoantibody positivity, initially misdiagnosed as anti‐synthetase syndrome due to interstitial ...
Beili Liu, Chao Xu, Yuqian Liu, Runze Song, Danbei Diwu, Fanqi Wu   +5 more
wiley   +1 more source

Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome

Respirology Case Reports, 2020
We report the first case of autoimmune pulmonary alveolar proteinosis (PAP) associated with and preceding myelodysplastic syndrome. A 74‐year‐old female with a history of polymyalgia rheumatica presented with six months history of progressive exertional ...
Chuan Tai Foo, Louis Chhor, Francis Thien   +2 more
doaj   +1 more source

Niche signals and transcription factors involved in tissue-resident macrophage development [PDF]

, 2018
Tissue-resident macrophages form an essential part of the first line of defense in all tissues of the body. Next to their immunological role, they play an important role in maintaining tissue homeostasis. Recently, it was shown that they are primarily of
Bonnardel, Johnny, Guilliams, Martin, T'Jonck, Wouter   +2 more
core   +2 more sources

Insuficiencia respiratoria neonatal asociada a mutación en el gen de la proteína C del surfactante [PDF]

, 2005
La insuficiencia respiratoria en el recién nacido a término durante las primeras semanas de vida extrauterina es una situación poco frecuente. Entre sus causas se incluyen las enfermedades difusas del intersticio pulmonar, un grupo heterogéneo de ...
Alava, E. (Enrique) de, Alzina, V. (Valentín), Bastero, P. (P.), Gaboli, M. (M.), Romero-Montero, A. (A.)   +4 more
core   +1 more source

Transfer RNA and small molecule therapeutics for aminoacyl‐tRNA synthetase diseases

The FEBS Journal, Volume 292, Issue 11, Page 2737-2750, June 2025.
Aminoacyl‐tRNA synthetases catalyze the ligation of a specific amino acid to a cognate tRNA—a reaction that lays the foundations for deciphering the genetic code. Pathogenic alleles in these synthetases can lead to dominant or recessive disorders, for which little or no disease‐specific treatments exist.
Tristan N. Samuels, Fanqi Wu, Maria Mahmood, Wajd A. Abuzaid, Nancy Sun, Angelica Moresco, Victoria M. Siu, Patrick O'Donoghue, Ilka U. Heinemann   +8 more
wiley   +1 more source

Impact of A Multidisciplinary Team Discussion for Genetic Lung Fibrosis

Respirology, Volume 30, Issue 6, Page 523-532, June 2025.
ABSTRACT Background and Objective Approximately 30% of individuals diagnosed with familial pulmonary fibrosis (FPF) exhibit a pathogenic variant upon genetic analysis. We established a genetic Multidisciplinary Discussion (geneMDD) aimed to enhance expertise in diagnosing and managing FPF.
Giovanni Franco, Ibrahima Ba, Nadia Nathan, Cécile Guerin, Albane Lassus, Caroline Kannengiesser, Antoine Froidure, Effrosyni Manali, Vincent Bunel, Philippe Bonniaud, Diane Bouvry, Marie Pierre Debray, Pierre Antoine Juge, Ralph Epaud, Camille Louvrier, Aurélie Plessier, Flore Sicre de Fontbrune, Lidwine Wémeau‐Stervinou, Sylvain Marchand Adam, Alexandre Chabrol, Arnaud Maurac, Laurent Savale, David Montani, Caroline Raynal, Marina Konyukh, Arthur Mageau, Bruno Crestani, Vincent Cottin, Alix de Becdelièvre, Raphaël Borie, Respifil and OrphaLung   +30 more
wiley   +1 more source

Granulocyte Macrophage Colony-Stimulating Factor-Specific Autoantibodies and Cerebral Nocardia With Pulmonary Alveolar Proteinosis

Open Forum Infectious Diseases, 2020
In this study, we report the history of a 40-year-old man with a primary cerebral abscess caused by Nocardia abscessus that led to the discovery of autoimmune pulmonary alveolar lipoproteinosis (anti-granulocyte-macrophage colony-stimulating factor [GM ...
Charlotte Berthoux, M. Mailhe, F. Vely, Clarisse Gauthier, J. Mege, J. Lagier, C. Melenotte   +6 more
semanticscholar   +1 more source

A case of uncomplicated pulmonary alveolar proteinosis evolving to pulmonary fibrosis

Monaldi Archives for Chest Disease, 2016
Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterised by intra-alveolar accumulation of surfactant components and cellular debris, with minimal interstitial inflammation or fibrosis.
A. Chroneou, N. Zias, B.S. Tronic, A.V. Gonzalez, J.F. Beamis Jr.   +4 more
doaj   +1 more source

Venoarterial extracorporeal membrane oxygenation (ECMO) for support during whole lung lavage for pulmonary alveolar proteinosis. [PDF]

, 2012
INTRODUCTION ECMO as support during whole lung lavage (WLL) for pulmonary alveolar proteinosis is reserved for severe cases where oxygenation is inadequate to support the patient using the ventilator alone.
Cavarocchi, Nicholas C, Hasan, Naveed, Hehn, Boyd, Hirose, Hitoshi, Monteagudo, Julie   +4 more
core   +2 more sources