Results 41 to 50 of about 8,530 (199)

Complete remission of pulmonary alveolar proteinosis after anti-tuberculous chemotherapy: a case report

Journal of International Medical Research, 2022
Pulmonary alveolar proteinosis (PAP) is a rare respiratory system disorder. Patients with PAP are at risk for a wide variety of secondary infections. This current case report describes a patient with PAP complicated by tuberculosis.
Guangtao Fan, Yilong Huang, Fenglin Xue, Bo He   +3 more
doaj   +1 more source

Highlights of the Brazilian Thoracic Association guidelines for interstitial lung diseases [PDF]

, 2012
Interstitial lung diseases (ILDs) are heterogeneous disorders, involving a large number of conditions, the approach to which continues to pose an enormous challenge for pulmonologists.
Aidé, Miguel Abidon, Algranti, Eduardo, Baldi, Bruno Guedes, Bethlem, Eduardo Pamplona, Capitani, Eduardo Mello de, Caramori, Marlova Luzzi, Carvalho, Carlos Roberto Ribeiro, Carvalho, Jozélio Freire de, Coletta, Ester Nei Aparecida Martins, Costa, André Nathan, Ferreira, Rimarcs Gomes, Jezler, Sérgio, Kairalla, Ronaldo Adib, Lima, Mariana Silva, Martinez, José Antônio Baddini, Oliveira, Rudolf Krawczenko Feitoza de, Ota-Arakaki, Jaquelina Sonoe, Pereira, Carlos Alberto de Castro, Pimenta, Suzana Pinheiro, Rocha, Marcelo Jorge Jacó, Rodrigues, Silvia Carla Sousa, Rubin, Adalberto Sperb, Santana, Alfredo Nicodemos da Cruz, Soares, Maria Raquel, Steidle, Leila John Marques   +24 more
core   +3 more sources

Unusual cause of dyspnea in patient with Myelofibrosis: The Ruxolitinib lung

Respiratory Medicine Case Reports
Although pulmonary complications are frequent in patients suffering from hematological diseases, secondary pulmonary alveolar proteinosis is a very rare complication of myelofibrosis.
Antoine El Kik, Maarten Vander Kuylen, Benjamin Bailly, Jennifer Fallas, Benjamin Bondue   +4 more
doaj   +1 more source

iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice

Stem Cell Reports, 2018
Summary: Induced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly attractive source for cell and gene therapy. Given the longevity, plasticity, and self-renewal potential of distinct macrophage subpopulations, iPSC-derived ...
Adele Mucci, Elena Lopez-Rodriguez, Miriam Hetzel, Serena Liu, Takuji Suzuki, Christine Happle, Mania Ackermann, Henning Kempf, Roman Hillje, Jessica Kunkiel, Ewa Janosz, Sebastian Brennig, Silke Glage, Jens P. Bankstahl, Sabine Dettmer, Thomas Rodt, Gudrun Gohring, Bruce Trapnell, Gesine Hansen, Cole Trapnell, Lars Knudsen, Nico Lachmann, Thomas Moritz   +22 more
doaj   +1 more source

Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

Nature Communications, 2021
Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. Here, the authors carry out a genome-wide association study of aPAP in a Japanese cohort, finding variants in the MHC and suggesting ...
Saori Sakaue, Etsuro Yamaguchi, Yoshikazu Inoue, Meiko Takahashi, Jun Hirata, Ken Suzuki, Satoru Ito, Toru Arai, Masaki Hirose, Yoshinori Tanino, Takefumi Nikaido, Toshio Ichiwata, Shinya Ohkouchi, Taizou Hirano, Toshinori Takada, Satoru Miyawaki, Shogo Dofuku, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Kotaro Ogawa, Tatsuo Masuda, Kenichi Yamamoto, Kyuto Sonehara, Ryushi Tazawa, Konosuke Morimoto, Masahiro Takaki, Satoshi Konno, Masaru Suzuki, Keisuke Tomii, Atsushi Nakagawa, Tomohiro Handa, Kiminobu Tanizawa, Haruyuki Ishii, Manabu Ishida, Toshiyuki Kato, Naoya Takeda, Koshi Yokomura, Takashi Matsui, Masaki Watanabe, Hiromasa Inoue, Kazuyoshi Imaizumi, Yasuhiro Goto, Hiroshi Kida, Tomoyuki Fujisawa, Takafumi Suda, Takashi Yamada, Yasuomi Satake, Hidenori Ibata, Nobuyuki Hizawa, Hideki Mochizuki, Atsushi Kumanogoh, Fumihiko Matsuda, Koh Nakata, Tomomitsu Hirota, Mayumi Tamari, Yukinori Okada   +56 more
doaj   +1 more source

Autoimmune pulmonary alveolar proteinosis in children

ERJ Open Research, 2022
In childhood, a multitude of causes lead to pulmonary alveolar proteinosis (PAP), an excessive surfactant accumulation in the alveolar space, limiting gas exchange.
Matthias Griese, Panagiota Panagiotou, Effrosyni D. Manali, Mirjam Stahl, Nicolaus Schwerk, Vanessa Costa, Konstantinos Douros, Maria Kallieri, Ruth Maria Urbantat, Horst von Bernuth, Lykourgos Kolilekas, Lurdes Morais, Ana Ramos, Kerstin Landwehr, Katrin Knoflach, Florian Gothe, Karl Reiter, Vassiliki Papaevangelou, Athanasios G. Kaditis, Christina Kanaka-Gantenbein, Spyros A. Papiris   +20 more
doaj   +1 more source

Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis [PDF]

, 2012
Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy,
Barna, Barbara P, Huizar, Isham, Karnekar, Reema, Kavuru, Mani S, Malur, Anagha, Marshall, Irene, NC DOCKS at East Carolina University, Thomassen, Mary Jane   +7 more
core   +3 more sources

Pulmonary Alveolar Proteinosis Syndrome [PDF]

Clinics in Chest Medicine, 2016
Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the accumulation of surfactant in alveoli and terminal airways resulting in respiratory failure. PAP comprises part of a spectrum of disorders of surfactant homeostasis (clearance and production).
Takuji, Suzuki, Bruce C, Trapnell
openaire   +2 more sources

Assessment of Surfactant Protein A (SP-A) dependent agglutination [PDF]

, 2010
Background: Monomers of the collectin surfactant associated protein-A (SP-A) are arranged in trimers and higher oligomers. The state of oligomerization differs between individuals and likely affects SP-A's functional properties.
Stefanie M Heinrich, Matthias Griese
core   +3 more sources

Expert‐Designed Fact Sheets and AI‐Based Analysis of Patient Symptoms to Combat Diagnostic Delays in Inherited Metabolic Diseases

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT The importance of early diagnosis of inherited metabolic diseases (IMDs) is well known, as it allows early intervention to prevent or reduce complications and improve prognosis, since many of these disorders are treatable. However, diagnosis can still be delayed, and many patients remain undiagnosed. Reducing diagnosis delays is a primary goal
Aline Cano, Xiaoyi Chen, Azza Khemiri, Anais Brassier, Arnoux Jean‐Baptiste, Roseline Froissart, Juliette Bouchereau, Célia Hoebeke, Karin Mazodier, Bénédicte Héron, Philippe Labrune, Catherine Caillaud, David Cheillan, Yann Nadjar, Samia Pichard, Apolline Imbard, Magali Pettazzoni, Claire Douillard, Belmatoug Nadia, Anna‐Line Calatayud, Mounira Zerguini, Nicolas Garcelon, Jean‐François Benoist, Cécile Acquaviva, Pascale De Lonlay, the other members of the expert group consortium, Marie‐Thérèse Abi‐Warde, Cécile Acquaviva, Jean‐Baptiste Arnoux, Stéphanie Badiou, Magalie Barth, Nadia Belmatoug, Jean‐François Benoist, Juliette Bouchereau, Anais Brassier, Arnaud Bruneel, Catherine Caillaud, Aline Cano, Brigitte Chabrol, David Cheillan, Emmanuelle Corbe‐Guillard, Christelle Corne, Lena Damaj, Myriam Dao, Pascale De Lonlay, Anne‐Frédérique Dessein, Dries Dobbelaere, Claire Douillard, Thierry Dupré, François Feillet, Roseline Froissart, Margaux Gaschignard, Magali Gorce, Laurent Gouya, Anne‐Sophie Guemann, Bénédicte Héron, Célia Hoebeke, Apolline Imbard, Elsa Kaphan, François Labarthe, Philippe Labrune, Pascal Laforet, Thierry Levade, Elise Lebigot, Edouard Le Guillou, Olivier Lidove, Julien Maquet, Wladimir Mauhin, Clothilde Marbach, Karin Mazodier, Karine Mention, Fanny Mochel, Caroline Moreau, Yann Nadjar, Esther Noel, Mickael Obadia, Cécile Pagan, Magali Pettazzoni, Samia Pichard, Clement Pontoizeau, Aurélia Poujois, Isabelle Redonnet‐Vernhet, Frédérique Sabourdy, Manuel Schiff, Christine Serratrice, Aude Servais, Caroline Sevin, Anne Spraul, Bénédicte Sudrié, Marine Tardieu, Sandrine Vuillaumier, Camille Wicker, Arnaud Wiedemann‐Fode, Vincent Barlogis, Nathalie Boddaert, Kanetee Busiah, Annabelle Chaussenot, Dominique Debray, Céline Falaise, Muriel Girard, Dalila Habes, Annie Harroche, Florence Lacaille, Mehdi Oualha, Caroline Ovaert, Rachel Reynaud, Caroline Rousset‐Rouvière, Cécile Rouzier, Karim Wahbi   +108 more
wiley   +1 more source