Results 51 to 60 of about 61,025 (285)

Sirolimus-induced secondary pulmonary alveolar proteinosis

Respiratory Medicine Case Reports, 2022
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary syndrome that is characterized by the accumulation of excess surfactant in the alveolar space, leading to impaired gas exchange. Sirolimus-induced PAP is an extremely rare entity that has only been
Stephanie Wang, MD, Elinor Lee, MD, PhD, Ryan Lau, MD, Tisha Wang, MD   +3 more
doaj   +1 more source

Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes [PDF]

, 2013
Background Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar proteinosis (PAP) are ...
Barna, Barbara P, Dalrymple, Heidi, Kavuru, Mani S, Malur, Achut G, Malur, Anagha, NC DOCKS at East Carolina University, Thomassen, Mary Jane   +6 more
core   +1 more source

Mavrilimumab, a fully human granulocyte-macrophage colony-stimulating factor receptor α monoclonal antibody: long-term safety and efficacy in patients with rheumatoid arthritis [PDF]

, 2018
Objective: Mavrilimumab, a human monoclonal antibody, targets granulocyte-macrophage colony-stimulating factor receptor alpha. We report mavrilimumab long-term safety and efficacy in rheumatoid arthritis patients in two phase IIb studies (1071, 1107 ...
Achuthan, Akagawa, Aletaha, Aletaha, Antoniu, Avci, Berghen, Borg, Borie, Brown, Buch, Burmester, Burmester, Calisto, Cella, Chen, Cook, Cornish, Cottin, Crotti, Dawson, Felson, Fleetwood, Fries, Greven, Guo, Hamilton, Jaguin, Kelly, Khan, Lazaro, Listing, Minter, Prevoo, Shaw, Shibata, Singh, Tsuchiya, Van der Heijde, Van Gestel, Van Onna, Ware, Weinblatt, Yoshida, Zhan   +44 more
core   +1 more source

Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study

Frontiers in Nutrition, 2021
Background: Lipids are known to accumulate abnormally in the alveoli and circulate during pulmonary alveolar proteinosis (PAP). However, the relationship between lipid ratios and PAP is not clear.
Xin Yan, Yujuan Gao, Qi Zhao, Xiaohua Qiu, Mi Tian, J. Dai, Zhuang Yi   +6 more
semanticscholar   +1 more source

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF [PDF]

, 2013
Tissue-resident macrophages can develop from circulating adult monocytes or from primitive yolk sac-derived macrophages. The precise ontogeny of alveolar macrophages (AMFs) is unknown. By performing BrdU labeling and parabiosis experiments in adult mice,
De Kleer, Ismé, De Prijck, Sofie, Deswarte, Kim, Guilliams, Martin, Hammad, Hamida, Henri, Sandrine, Lambrecht, Bart, Malissen, Bernard, Post, Sijranke, Vanhoutte, Leen   +9 more
core   +2 more sources

Therapeutic effect of subcutaneous injection of low dose recombinant human granulocyte-macrophage colony-stimulating factor on pulmonary alveolar proteinosis

Respiratory Research, 2020
ObjectiveTo observe the efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) for pulmonary alveolar proteinosis (PAP).Materials and methodsA total of 55 patients with PAP were screened at Shanghai Pulmonary Hospital ...
Fen Zhang, D. Weng, Yi-liang Su, Chengsheng Yin, Li Shen, Y. Zhang, Ying Zhou, Qiuhong Li, Yang Hu, Huiping Li   +9 more
semanticscholar   +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Pulmonary alveolar proteinosis in a cat [PDF]

BMC Veterinary Research, 2015
Pulmonary alveolar proteinosis is an extremely rare lung disease in animals and humans. It is characterized by the deposition of a large amount of phospholipoproteinaceous material in the alveoli. There are several possible etiologies, both congenital and acquired. Alveolar macrophages play an important role in the clearance of surfactant.
Szatmári, Viktor, Teske, Erik, Nikkels, Peter G J, Griese, Matthias, de Jong, Pim A, Grinwis, Guy, Theegarten, Dirk, Veraa, Stefanie, van Steenbeek, Frank G, Drent, Marjolein, Bonella, Francesco   +10 more
openaire   +6 more sources

Long-term follow-up and successful treatment of pulmonary alveolar proteinosis without hypercholesterolemia with statin therapy: a case report

Journal of International Medical Research, 2021
Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the accumulation of excessive surfactant lipids and proteins in alveolar macrophages and alveoli. Oral statin therapy is a novel treatment for PAP with hypercholesterolemia. However,
Shenyun Shi, Rujia Wang, Ling Chen, Yan Li, Yingwei Zhang, Xiaoyan Xin, Shangwen Yang, Yihua Wang, Yonglong Xiao, Kaifeng Xu   +9 more
semanticscholar   +1 more source

Simultaneous presentation of two noninflammatory lung diseases in an HIV-infected patient

Annals of Thoracic Medicine, 2017
The simultaneous presentation of two noninflammatory pulmonary diseases, pulmonary alveolar proteinosis and Kaposi's sarcoma (Ks), in an HIV-infected patient, is described.
Rafael Martínez-Girón, Santiago Martínez-Torre   +1 more
doaj   +1 more source