Results 81 to 90 of about 8,581 (204)

Aggressive Head and Neck Squamous Cell Carcinoma in the Setting of GATA2 Deficiency

Head &Neck, Volume 47, Issue 7, Page E82-E86, July 2025.
ABSTRACT Background GATA2 deficiency is a rare genetic disorder associated with hematologic, infectious, and neoplastic complications. We report a case of a patient with GATA2 deficiency who developed aggressive squamous cell carcinoma (SCC) of the head and neck, an atypical manifestation of this condition.
Brejjette Aljabi, James A. Stewart, Kirk Withrow, Carissa M. Thomas   +3 more
wiley   +1 more source

Effective hematopoietic stem cell-based gene therapy in a murine model of hereditary pulmonary alveolar proteinosis

Haematologica, 2020
Hereditary pulmonary alveolar proteinosis due to GM-CSF receptor deficiency (herPAP) constitutes a life-threatening lung disease characterized by alveolar deposition of surfactant protein secondary to defective alveolar macrophage function.
Miriam Hetzel, Elena Lopez-Rodriguez, Adele Mucci, Ariane Hai Ha Nguyen, Takuji Suzuki, Kenjiro Shima, Theresa Buchegger, Sabine Dettmer, Thomas Rodt, Jens P. Bankstahl, Punam Malik, Lars Knudsen, Axel Schambach, Gesine Hansen, Bruce C. Trapnell, Nico Lachmann, Thomas Moritz   +16 more
doaj   +1 more source

Silicosis Mimicking Lung Malignancy: A Case Series

Respirology Case Reports, Volume 13, Issue 7, July 2025.
This case series describes three patients that were suspected to have a primary lung malignancy based on FDG‐PET findings, but were found to have pulmonary silicosis. With this series, we demonstrate how histologic examination can differentiate between silicosis and malignancy and provide suggestions to help clinicians differentiate between these two ...
Titia van Duin, Carmen Ambarus, Wouter van Es, Sophie van der Mark, Franz Schramel   +4 more
wiley   +1 more source

Pulmonary alveolar proteinosis: diagnosis using routinely processed smears of bronchoalveolar lavage fluid. [PDF]

, 1997
AIMS: For the diagnosis of pulmonary alveolar proteinosis from bronchoalveolar lavage specimens it is normally necessary to make an ultrastructural examination.
I Okayasu, M Yokoyama, T Mikami, Y Yamamoto   +3 more
core   +2 more sources

Telomere Shortening in Interstitial Lung Disease: Challenges and Promises

The Clinical Respiratory Journal, Volume 19, Issue 7, July 2025.
Telomerase abnormalities such as related gene mutations lead to decrease in telomerase activity and telomere shortening. Individual cells undergoing continuous division exhibit telomere shortening. A successive shortening of the telomere results in dysfunctional telomeres.
Haonan Jin, Jiamin Song, Ronglin Gao, Bingxian Sha, Shengyuan Wang, Peiming Luo, Li Yu, Xianghuai Xu, Xuan Wang   +8 more
wiley   +1 more source

Gravidez de termo em doente com proteinose alveolar e insuficiência respiratória grave

Revista Portuguesa de Pneumologia, 2011
Resumo: A proteinose alveolar pulmonar (PAP) é uma doença rara caracterizada pela acumulação anormal de material lipoproteináceo nos alvéolos, que pode levar a insuficiência respiratória, estando associada a um risco elevado de infecções.
I. Belchior, A.S. Cerdeira, M. Santos, J. Sousa Braga, I. Aragão, A. Martins   +5 more
doaj   +1 more source

Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome

Respirology Case Reports, 2020
We report the first case of autoimmune pulmonary alveolar proteinosis (PAP) associated with and preceding myelodysplastic syndrome. A 74‐year‐old female with a history of polymyalgia rheumatica presented with six months history of progressive exertional ...
Chuan Tai Foo, Louis Chhor, Francis Thien   +2 more
doaj   +1 more source

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 22: Suitability of taxonomic units notified to EFSA until March 2025

EFSA Journal, Volume 23, Issue 7, July 2025.
Abstract The qualified presumption of safety (QPS) process was developed to assess the safety of microorganisms used in food and feed chains. During the period covered by this Statement, no new information warranted changes to the status of previously recommended QPS taxonomic units.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Juan Evaristo Suarez, Marianne Chemaly, Ingvar Sundh, Fulvio Barizzone, Justine Dastouet, Nadya Doyle, Sandra Correia, Lieve Herman   +28 more
wiley   +1 more source

Venoarterial extracorporeal membrane oxygenation (ECMO) for support during whole lung lavage for pulmonary alveolar proteinosis. [PDF]

, 2012
INTRODUCTION ECMO as support during whole lung lavage (WLL) for pulmonary alveolar proteinosis is reserved for severe cases where oxygenation is inadequate to support the patient using the ventilator alone.
Cavarocchi, Nicholas C, Hasan, Naveed, Hehn, Boyd, Hirose, Hitoshi, Monteagudo, Julie   +4 more
core   +2 more sources

Silicosarcoidosis: Histologic and Clinical Features of an Occupational Granulomatous Disease

American Journal of Industrial Medicine, Volume 68, Issue 6, Page 491-507, June 2025.
ABSTRACT Sarcoidosis is a multisystem inflammatory disease of unknown etiology. Growing evidence indicates that occupational exposure to respirable crystalline silica (RCS) is associated with an increased incidence of sarcoidosis. Yet a diagnosis of sarcoidosis rarely prompts investigation to identify preventable exposures.
Jeremy T. Hua, Carlyne D. Cool, Einat Fireman Klein, Yochai Adir, Lukas J. Lee, Lauren M. Zell‐Baran, Robert A. Cohen, Richard C. Kraus, E. Brigitte Gottschall, Silpa D. Krefft, Charles Van Hook, Cecile S. Rose   +11 more
wiley   +1 more source