Results 171 to 180 of about 2,645,233 (222)
Animal Models and Experimental Medicine, EarlyView.Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao +6 more
wiley +1 more source
Application of humanized mice in the safety experiments of antibody drugs
Animal Models and Experimental Medicine, EarlyView.The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun +9 more
wiley +1 more source
Establishment of rat model for aspiration pneumonia and potential mechanisms
Animal Models and Experimental Medicine, EarlyView.Aspiration pneumonia was induced in Sprague Dawley rats by intratracheal instillation of hydrochloric acid (HCl, 1.5 μL/g.wt, pH = 1) followed by lipopolysaccharide (LPS, 20 μg/g.wt) after 1 h. The model reproduced hallmark features of acute lung injury, including histological lung damage, microvascular dysfunction, inflammation, hypoxemia, and ...
Hanbing Hu +7 more
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Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection
Animal Models and Experimental Medicine, EarlyView.This review explores the potential mechanisms, complications, risk factors, and future research directions related to osteoporosis secondary to SARS‐CoV‐2 infection. Key mechanisms include an imbalance between osteoclast and osteoblast activity driven by direct viral effects on bone, inflammation, hypoxia, dysregulation of noncoding RNAs, and metabolic
Jinlong Wang +5 more
wiley +1 more source
An optimized perfusate for enhanced rat ex vivo lung perfusion and lung transplant models
Animal Models and Experimental Medicine, EarlyView.We explored a low‐cost and efficient perfusate composition for use in rat ex vivo lung perfusion (EVLP) and lung transplant models. This perfusate demonstrates better biocompatibility, likely due to a reduction in immune responses associated with high doses of xenogenic proteins, resulting in less lung injury posttransplantation.
Jie Zhang, Xuanlin Zhang, Jianxing He
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Animal Models and Experimental Medicine, EarlyView.Here, we developed a novel Chinese hamster genetic quality detection system using single‐nucleotide polymorphism (SNP) markers following this process. To obtain SNP loci, we conducted whole genome sequencing on 24 Chinese hamsters. Then, we employed an SNP loci screening criterion that we set up previously and initially screened 214 SNP loci with wide ...
Minghe Sun +14 more
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Automated Detection of Isolated REM Sleep Behavior Disorder Using Computer Vision
Annals of Neurology, EarlyView.Objective Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is, in most cases, an early stage of Parkinson's disease or related disorders. Diagnosis requires an overnight video‐polysomnogram (vPSG), however, even for sleep experts, interpreting vPSG data is challenging.
Mohamed Abdelfattah +11 more
wiley +1 more source
Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention
Annals of Neurology, EarlyView.The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators.
Alison M. H. Donald +16 more
wiley +1 more source
Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship
Annals of Neurology, EarlyView.Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino +4 more
wiley +1 more source