Results 171 to 180 of about 676,655 (309)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Chronic course of human T-cell lymphotropic virus type-1-associated bronchioloalveolar disorder diagnosed using transbronchial lung cryobiopsy. [PDF]

Respir Med Case Rep
Hiromi A, Yamakawa H, Ohta H, Kusano K, Adachi A, Yamaguchi Y, Matsushima H.   +6 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Quantitative Imaging Markers on HRCT Predict Rapid Progression and Adverse Events of Patients with Idiopathic Inflammatory Myopathies-Related Interstitial Lung Disease

International Journal of General Medicine
Hongyi Wang,1,2,* Yuhui Qiang,2– 4,* Jianping Wang,3,5 Yifei Ni,1,5 Anqi Liu,1,5 Jie Du,1,5 Yanhong Ren,2 Shiyao Wang,2 Jing Geng,2 Bingbing Xie,2 Min Liu,5 Huaping Dai2 1China-Japan Friendship Hospital (Institute of Clinical Medical ...
Wang H, Qiang Y, Wang J, Ni Y, Liu A, Du J, Ren Y, Wang S, Geng J, Xie B, Liu M, Dai H   +11 more
doaj  

Addressing the Global Challenges of COPD and Asthma: A Shared Vision From the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) and the Global Initiative for Asthma (GINA). [PDF]

Respirology
Halpin DMG, Masekela R, Vogelmeier CF, Ozoh OB, Cruz AA, Reddel HK, Yorgancıoğlu A, Agusti A, Boards of Directors of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and Global Initiative for Asthma (GINA).   +8 more
europepmc   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

An extremely rare tetralogy of Fallot with absent pulmonary valve and unilateral absence of the pulmonary artery: a rare report of De Bucket Syndrome. [PDF]

Egypt Heart J
Jalali A, Mahdavi M, Ganjifard M, Nabavi SS, Bakhtiari M, Ansari Aval Z, Hosseini Zargaz SE.   +6 more
europepmc   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Exercise-Induced Oxygen Desaturation and Cognitive Performance in Patients with Parkinson's Disease: A Prospective Observational Study. [PDF]

J Clin Med
Gache AC, Danteș E, Postu AC, Ion-Andrei DG, Man AM, Șerban NL, Rășanu I, Axelerad A.   +7 more
europepmc   +1 more source

Rethinking Power Solutions for Healthcare Wearables: From Point‐of‐Care and Episodic use to Continuous Monitoring and Therapeutic Platforms

Advanced Energy and Sustainability Research, EarlyView.
This Perspective examines practical power solutions for wearable healthcare systems, highlighting the limits of standard batteries. It categorizes wearables into four domains—point‐of‐care diagnostics, episodic monitoring, continuous long‐term monitoring, and therapeutic platforms—and analyzes their power needs.
Seokheun Choi
wiley   +1 more source