Results 211 to 220 of about 622,177 (374)

Engineered Anti‐Senescence Trachea With Post‐Transplanted Regenerative Homeostasis

open access: yesAdvanced Science, EarlyView.
Bioengineered trachea undergoes post‐transplanted senescence, which is found in this study for the first time. Hebe‐ET is designed with dual anti‐senescence strategies: fiber‐film scaffold in cartilage rings for close‐packed cell interaction, and quercetin‐loaded fibrous rings for immune modulation.
Ziyin Pan   +14 more
wiley   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

open access: yesAdvanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang   +12 more
wiley   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He   +11 more
wiley   +1 more source

The microbiome in respiratory medicine: current challenges and future perspectives

open access: yesEuropean Respiratory Journal, 2017
R. Faner   +13 more
semanticscholar   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

open access: yesAdvanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim   +7 more
wiley   +1 more source

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