Results 21 to 30 of about 8,378 (218)

The diagnostic value of transbronchial lung cryobiopsy combined with rapid on-site evaluation in diffuse lung diseases: a prospective and self-controlled study

BMC Pulmonary Medicine, 2022
Background The etiology of interstitial lung diseases (ILDs) is varied. Early diagnosis and a specific pathological type could significantly improve the prognosis.
Xianqiu Chen, Jie Luo, Li Yang, Likun Hou, Bing Jie, Yang Hu, Jianxiong Li, Xing Jiang, Jinfu Xu, Kebin Cheng   +9 more
doaj   +1 more source

Impact of targeted pulmonary arterial hypertension therapies in severe pulmonary hypertension in chronic lung diseases

ERJ Open Research, 2023
Research questions Patients with severe pulmonary hypertension associated with chronic lung disease have a poor prognosis. Targeted pulmonary arterial hypertension therapies might improve exercise capacity and outcome, but there are no guidelines on ...
Romain Naud, Julien Bermudez, Noémie Resseguier, Ana Nieves, Bérengère Coltey, Nadine Dufeu, Clarisse Gautier, Youssef Trigui, Marc Laine, Benjamin Coiffard, Martine Reynaud-Gaubert   +10 more
doaj   +1 more source

Eosinophil extracellular traps in asthma: implications for pathogenesis and therapy

Respiratory Research, 2023
Asthma is a common, chronic inflammatory disease of the airways that affects millions of people worldwide and is associated with significant healthcare costs.
Kunlu Shen, Mengyuan Zhang, Ruiheng Zhao, Yun Li, Chunxiao Li, Xin Hou, Bingqing Sun, Bowen Liu, Min Xiang, Jiangtao Lin   +9 more
doaj   +1 more source

Diagnostic performance of a doppler radar-based sleep apnoea testing device

BMC Pulmonary Medicine
Background Inpatient polysomnography (PSG) is the gold standard for the diagnosis of obstructive sleep apnoea (OSA), however, both complexity and costs limit the availability of this examination.
Jonathan Röcken, Andrei M. Darie, Leticia Grize, Claire Ellen Dexter, Matthias J. Herrmann, Kathleen Jahn, Werner Strobel, Michael Tamm, Daiana Stolz   +8 more
doaj   +1 more source

Urban particulate matter (PM) suppresses airway antibacterial defence

Respiratory Research, 2018
Background Epidemiological studies have shown that urban particulate matter (PM) increases the risk of respiratory infection. However, the underlying mechanisms are poorly understood. PM has been postulated to suppress the activation of airway epithelial
Xiaoyan Chen, Jinguo Liu, Jian Zhou, Jian Wang, Cuicui Chen, Yuanlin Song, Jue Pan   +6 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Successful management of refractory respiratory failure caused by avian influenza H7N9 and secondary organizing pneumonia: a case report and literature review

BMC Infectious Diseases, 2019
Backgroud Organizing pneumonia (OP) is a rare complication of influenza infection that has substantial morbidity. We report the first case of OP associated with avian influenza H7N9 infection that had significant improvement with corticosteroid treatment.
Hangyong He, Hao Wang, Xuyan Li, Xiao Tang, Bing Sun, Zhaohui Tong   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Endothelial dysfunction is not a predictor of outcome in chronic obstructive pulmonary disease

Respiratory Research, 2020
Background Local airway inflammation may cause systemic changes which result in endothelial dysfunction. Only a few studies have used reactive hyperemia peripheral arterial tonometry (RH-PAT) in patients with chronic obstructive pulmonary disease (COPD ...
Andreas Scherr, Desiree M. Schumann, Meropi Karakioulaki, Léo Franchetti, Werner Strobel, Michael Zellweger, Michael Tamm, Daiana Stolz   +7 more
doaj   +1 more source