Results 161 to 170 of about 591,821 (395)

Three-dimensional echocardiography and 2D-3D speckle tracking imaging in chronic pulmonary hypertension. diagnostic accuracy in detecting hemodynamic signs of RV failure [PDF]

, 2015
Background and objective. Our aim was to compare three-dimensional (3D) and 2D and 3D speckle tracking (2D-STE, 3D-STE) echocardiographic parameters with conventional right ventricular (RV) indexes in patients with chronic pulmonary hypertension (PH ...
Alessia, Azzano, Capotosto, Lidia, Gaudio, Carlo, Mangieri, Enrico, Nino, Cocco, Rasul, Ashurov, Rosato, Edoardo, Salsano, Felice, Simona, D’Orazio, Terzano, Claudio, Truscelli, Giovanni, Vitarelli, Antonino   +11 more
core   +1 more source

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Nature Communications, 2018
Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious variation within components of the transforming growth factor-β pathway, particularly the bone morphogenetic protein type 2 receptor (BMPR2), underlies most ...
S. Gräf, Matthias Haimel, M. Bleda, C. Hadinnapola, L. Southgate, Wei Li, J. Hodgson, Bin Liu, R. Salmon, M. Southwood, R. Machado, Jennifer M Martin, C. Treacy, Katherine Yates, L. Daugherty, O. Shamardina, Deborah Whitehorn, Simon Holden, M.A. Aldred, H. Bogaard, Colin Church, G. Coghlan, R. Condliffe, P. Corris, C. Danesino, M. Eyries, Henning Gall, S. Ghio, H. Ghofrani, J. S. R. Gibbs, B. Girerd, A. Houweling, Luke Howard, Marc Humbert, David Kiely, Gabor Kovacs, R. M. MacKenzie Ross, S. Moledina, D. Montani, M. Newnham, Andrea Olschewski, H. Olschewski, Andrew J. Peacock, Joanna Pepke-Zaba, I. Prokopenko, Christopher J. Rhodes, L. Scelsi, W. Seeger, F. Soubrier, D. Stein, J. Suntharalingam, E. Swietlik, Mark R. Toshner, D. V. van Heel, A. Vonk Noordegraaf, Q. Waisfisz, J. Wharton, S. Wort, W. Ouwehand, N. Soranzo, A. Lawrie, P. Upton, Martin R. Wilkins, R. Trembath, Nicholas W Morrell   +64 more
semanticscholar   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Relationship of daily arterial blood pressure monitoring readings and arterial stiffness profile in male patients with chronic obstructive pulmonary disease combined with arterial hypertension [PDF]

, 2013
The aim of the study was to determine correlation between arterial blood pressure daily rhythm and daily profile of arterial stiffness in male patients with chronic obstructive pulmonary disease (COPD) and arterial hypertension.
Borodkin A.M., Dolishnyaya G.R., Karoli N.A., Rebrov A.P.   +3 more
core  

Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. [PDF]

, 2013
BACKGROUND: Riociguat, a member of a new class of compounds (soluble guanylate cyclase stimulators), has been shown in previous clinical studies to be beneficial in the treatment of chronic thromboembolic pulmonary hypertension. METHODS: In this phase 3,
CHEST-1 Study Group,, D'Armini, AM, Fritsch, A, Ghofrani, HA, Grimminger, F, Hoeper, MM, Jansa, P, Kim, NH, Mayer, E, Neuser, D, Simonneau, G, Wang, C, Weimann, G, Wilkins, MR   +13 more
core   +1 more source

PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.

American Journal of Respiratory and Critical Care Medicine, 2019
RATIONALE Glycolytic shift is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). It remains unknown how glycolysis is increased and how increased glycolysis contributes to pulmonary vascular remodeling in PAH.
L. Kovács, Yapeng Cao, Weihong Han, Louise Meadows, A. Kovács-Kása, D. Kondrikov, A. Verin, S. Barman, Z. Dong, Yuqing Huo, Yunchao Su   +10 more
semanticscholar   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Outcome of patients with pulmonary arterial hypertension referred for lung transplantation: A 14-year single-center experience [PDF]

, 2012
Marc de Perrot, John Granton, Karen McRae, Andrew F. Pierre, L.G. Singer, Thomas K. Waddell, Shaf Keshavjee   +6 more
openalex   +1 more source

CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension

Nature Communications, 2019
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of cardiopulmonary units. No cure is currently available due to an incomplete understanding of vascular remodeling.
Yongting Luo, Xiao Teng, Lingling Zhang, Jianan Chen, Zheng Liu, Xuehui Chen, Shuai Zhao, Sai Yang, Jing Feng, Xiyun Yan   +9 more
semanticscholar   +1 more source

Preoperative Aortic Calcification Volume Predicts Postoperative Complications in Nonpancreatic Cancer Patients Undergoing Pancreaticoduodenectomy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background/Objectives Postoperative complications following pancreaticoduodenectomy (PD) remain high, particularly in patients with soft pancreatic texture. Abdominal aortic calcification volume (AACV), a surrogate marker of systemic arteriosclerosis, has been associated with increased surgical risk in lower gastrointestinal procedures ...
Masaki Horiuchi, Kentaro Miyake, Kota Sahara, Jun Yamamoto, Yutaro Kikuchi, Yasuhiro Yabushita, Yu Sawada, Yuki Homma, Ryusei Matsuyama, Itaru Endo   +9 more
wiley   +1 more source