Results 161 to 170 of about 560,791 (351)

Effects of bosentan on cellular processes involved in pulmonary arterial hypertension: do they explain the long‐term benefit? [PDF]

, 2003
Martine Clozel
openalex   +1 more source

Neonatal pulmonary hypertension prevents reorganisation of the pulmonary arterial smooth muscle cytoskeleton after birth

, 2000
Susan Hall, M Gorenflo, Jayne A Reader, Durward Lawson, Sheila G. Haworth   +4 more
openalex   +2 more sources

Sildenafil for Pulmonary Arterial Hypertension [PDF]

, 2003
Sanjay Mehta
openalex   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Pulmonary arterial remodeling revealed by microfocal x-ray tomography [PDF]

, 2001
Animal models and micro-CT imaging are useful for understanding the functional consequences of, and identifying the genes involved in, the remodeling of vascular structures that accompanies pulmonary vascular disease.
Dawson, Christopher A, Dhyani, Anita H., Haworth, Steven Thomas, Karau, Kelly L., Molthen, Robert C.   +4 more
core   +1 more source

Sitaxsentan in Pulmonary Arterial Hypertension [PDF]

, 2003
Sotiria C. Apostolopoulou, Spyridon Rammos   +1 more
openalex   +1 more source

Effectiveness and Safety of Reduced‐Dose Prasugrel in an East Asian Population: PRASFIT‐ACS Emulation Using National Health Insurance Claims Data

Clinical Pharmacology &Therapeutics, EarlyView.
Prasugrel is recommended for acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). However, East Asians exhibit a stronger antiplatelet response, raising concerns about bleeding risks with standard dosing. This retrospective cohort study evaluated the real‐world effectiveness and safety of reduced‐dose prasugrel in
Li‐Wen Huang, Yee‐Jen Wu, Fang‐Ju Lin, Chien‐Chih Wu, Hsin‐Yi Huang, Chi‐Chuan Wang, Xiaojuan Li   +6 more
wiley   +1 more source

475 The value of pressure Strain loops in the assessment of right ventricular regional function in patients with pulmonary arterial hypertension [PDF]

, 2003
Virginija Teresė Dambrauskaitė, Piet Claus, Jan D’hooge, Bart Bijnens, Marie‐Christine Herregods, Marion Delcroix, G SUTHERLAND   +6 more
openalex   +1 more source

Expediting Drug Development in Japan: A PMDA Perspective

Clinical Pharmacology &Therapeutics, EarlyView.
Review time for a new drug in Japan has shortened dramatically since the establishment of the Pharmaceuticals and Medical Devices Agency (PMDA). Nonetheless, Japan faces a new challenge so‐called “Drug Loss”, which means that new drugs approved overseas have not yet been developed in Japan or that development is delayed. In this manuscript, we describe
Yoichi Kohno, Akihiro Ishiguro, Takashi Yasukawa, Naoyuki Yasuda, Daisuke Tanaka, Yasuhiro Araki, Yukio Takahashi, Yoshiaki Uyama, Yasuhiro Fujiwara   +8 more
wiley   +1 more source

Hierarchical clustering of clinical and flow cytometry parameters is associated with deterioration in patients with community‐acquired pneumonia in the emergency department: A preliminary study

Cytometry Part B: Clinical Cytometry, EarlyView.
ABSTRACT Anticipating the evolution of septic patients with community‐acquired pneumonia (CAP) is challenging for front‐line physicians in the Emergency Department (ED). Prognosis depends mainly on early identification, antibiotics, organ support, but also immune status.
Thomas Lafon, Robin Jeannet, Thomas Daix, Guillaume Monneret, Jean Feuillard   +4 more
wiley   +1 more source