Results 321 to 330 of about 2,608,517 (407)

Fibrosing Mediastinitis and Complete Right Pulmonary Artery Occlusion. [PDF]

Anatol J Cardiol
Ufuk F.
europepmc   +1 more source

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Association Between Bicuspid Aortic Valve and Main Pulmonary Artery Dilation in Adult Patients. [PDF]

JACC Adv
Hay AV, Ledingham L, Ma J, Peng J, Marshall V WH, Gil KE, Daniels CJ, Rajpal S.   +7 more
europepmc   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

A novel iron bioresorbable scaffold: a potential strategy for pulmonary artery stenosis. [PDF]

Regen Biomater
Qin L, Zhang G, Sun L, Yu Z, Zhang Z, Sun L, Zhang W, Fu W, Ou Y, Zhang W, Shi X, Si Z, Shen J, Cha L, Zhang Z, Zhang D.   +15 more
europepmc   +1 more source

Effectiveness and Safety of Reduced‐Dose Prasugrel in an East Asian Population: PRASFIT‐ACS Emulation Using National Health Insurance Claims Data

Clinical Pharmacology &Therapeutics, EarlyView.
Prasugrel is recommended for acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). However, East Asians exhibit a stronger antiplatelet response, raising concerns about bleeding risks with standard dosing. This retrospective cohort study evaluated the real‐world effectiveness and safety of reduced‐dose prasugrel in
Li‐Wen Huang, Yee‐Jen Wu, Fang‐Ju Lin, Chien‐Chih Wu, Hsin‐Yi Huang, Chi‐Chuan Wang, Xiaojuan Li   +6 more
wiley   +1 more source

Point-of-Care Ultrasound for Guiding Pulmonary Artery Catheter Placement. [PDF]

CASE (Phila)
Su E, Flores S.
europepmc   +1 more source

Expediting Drug Development in Japan: A PMDA Perspective

Clinical Pharmacology &Therapeutics, EarlyView.
Review time for a new drug in Japan has shortened dramatically since the establishment of the Pharmaceuticals and Medical Devices Agency (PMDA). Nonetheless, Japan faces a new challenge so‐called “Drug Loss”, which means that new drugs approved overseas have not yet been developed in Japan or that development is delayed. In this manuscript, we describe
Yoichi Kohno, Akihiro Ishiguro, Takashi Yasukawa, Naoyuki Yasuda, Daisuke Tanaka, Yasuhiro Araki, Yukio Takahashi, Yoshiaki Uyama, Yasuhiro Fujiwara   +8 more
wiley   +1 more source