Results 171 to 180 of about 31,959 (340)

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

MR‐DELTAnet: A Longitudinal MRI‐Transformer Model Predicting Pathological Complete Response and Revealing Immune Microenvironment via scRNA‐seq in Locally Advanced Rectal Cancer

Advanced Science, EarlyView.
The MR‐DELTAnet model utilizes longitudinal MRI to predict treatment response after neoadjuvant chemoradiotherapy in locally rectal cancer patients, accurately identifying patients likely to achieve pathological complete response for personalized management.
Wuteng Cao, Huaxian Chen, Jiao Li, Yihui Zheng, Liqing Xie, Guozhong Xiao, Zeyan Wang, Fen Yuan, Junhong Chen, Chongbao Sun, Jing Dai, Jinping Zeng, Xinhua Wang, Lei Wu, Hongcheng Lin   +14 more
wiley   +1 more source

Micro‐Organ Chip Deciphers Tumor‐Derived G‐CSF as Remote Commander of Lung Pre‐Metastatic Niche via VEGFA‐KDR Cascade

Advanced Science, EarlyView.
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Jingxin Zhang, Xiaoying Huang, Lingchuan Ma, Zixing Chen, Tianyao Li, Lijian Wang, Yutong Guo, Hu Xu, Junqi Li, Jiang‐Jiang Qin, Xiang Wang, Yuhong Cao, Kai Miao   +12 more
wiley   +1 more source

Significance of diffusing capacity of the lungs for carbon monoxide on chronic thromboembolic pulmonary hypertension [PDF]

Shun Minatsuki, Masaru Hatano, Kouta Funakoshi, Yu Taniguchi, Shiro Adachi, Takumi Inami, Kazuya Hosokawa, Jun Yamashita, Hitoshi Ogino, Ichizo Tsujino, Nobuhiro Yaoita, Nobutaka Ikeda, Nobuhiro Tanabe, Hiroto Shimokawahara, Kayoko Kubota, Ayako Shigeta, Koichiro Tatsumi, Koshin Horimoto, Yoshito Ogihara, Yoshihiro Dohi, Takahiro Hiraide, Takashi Kawakami, Hidekazu Ikemiyagi, Yuichi Tamura, Y. Fukumoto, Kohtaro Abe   +25 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Small Airways and Pulmonary Diffusing Capacity Decline in an 8‐Year Longitudinal Population Study [PDF]

Sara Maio, Anna Angino, Sandra Baldacci, Giuseppe Sarno, Ilaria Stanisci, Laura Carrozzi, Giovanni Viegi, Francesco Pistelli   +7 more
openalex   +1 more source

Pulmonary complications after lung resection in the absence of chronic obstructive pulmonary disease: The predictive role of diffusing capacity [PDF]

, 2009
Mark K. Ferguson, Henning A. Gaissert, Joshua D. Grab, Shubin Sheng   +3 more
openalex   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source

PULMONARY DIFFUSING CAPACITY DURING REST AND EXERCISE. A STUDY OF NORMAL PERSONS AND PERSONS WITH ATRIAL SEPTAL DEFECT, PREGNANCY, AND PULMONARY DISEASE* [PDF]

, 1962
George N. Bedell, Richard W. Adams
openalex   +1 more source

The Single Breath Diffusing Capacity for Carbon Monoxide in Patients with Idiopathic Pulmonary Fibrosis: 6 Month Variability and Its Role in Predicting Forced Vital Capacity Change [PDF]

, 2021
S.D. Nathan, MS Lan Yang, J.L. Stauffer
openalex   +1 more source