Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang +5 more
wiley +1 more source
IL-33 as a biomarker for disease severity in COPD with lung cancer comorbidity. [PDF]
Am J Cancer ResRen H, Cui Y, Lv X.
europepmc +1 more source
Research advances in dysphagia animal models
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai +5 more
wiley +1 more source
The Association Between COPD, Acute Exacerbations of COPD, and Survival in COPD, with Fat-Free Body Mass Index: A Systematic Review and Meta-Analysis. [PDF]
Int J Chron Obstruct Pulmon DisHu C, Song B, Liu X, Sun L, Li M, He X.
europepmc +1 more source
Diosgenin ameliorates silica‐induced tuberculosis in rats
Animal Models and Experimental Medicine, EarlyView.Silicosis increases susceptibility to tuberculosis due to impaired macrophage function and oxidative stress. This study demonstrates that diosgenin, a steroidal saponin, significantly inhibits Mycobacterium smegmatis (IC₅₀ = 0.006 μg/mL), reduces lung fibrosis, and restores antioxidant enzyme levels (↑SOD, ↑CAT, ↓MDA) in silica‐exposed rats ...
Williams Asamoah Adu +5 more
wiley +1 more source
Treatment Patterns and Triple Therapy Utilization in Chinese Patients with Chronic Obstructive Pulmonary Disease: An Analysis of Real-World Data from the Yinzhou Database. [PDF]
Int J Chron Obstruct Pulmon DisChen Y +11 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.This study investigated changes in pulmonary artery hemodynamics using a Flowire catheter and evaluated the accuracy of Doppler echocardiography in dogs with acute pulmonary thromboembolism (PTE). Ten healthy beagles were anesthetized, and acute pulmonary hypertension (PH) was induced by injecting 300‐μm dextran microspheres.
Tomohiko Yoshida +3 more
wiley +1 more source
Correlation Between Chronic Obstructive Pulmonary Disease Severity and Nutritional Status: A Cross-Sectional Study From a Tertiary Care Center in South India. [PDF]
CureusPriya K +6 more
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.GA: Bioprinting‐assisted tissue assembly, a method for generating versatile and complex tissue constructs, is employed to investigate the contribution of endothelial cells (ECs) in cardiac fibrosis. ECs modulate fibrotic responses not only by preventing significant tissue stiffening and contractile impairment but also by exhibiting endothelial‐to ...
Dong Gyu Hwang +6 more
wiley +1 more source