Results 51 to 60 of about 725,283 (343)

The efficacy of psychologically based interventions to improve anxiety, depression and quality of life in COPD: a systematic review and meta-analysis [PDF]

, 2012
This article comprises a systematic review and meta-analysis looking at the efficacy of psychological intervention in improving anxiety, depression and quality of life in respiratory disease.Objective: To systematically evaluate the efficacy of ...
Adams, Amy Baraniak, Burgess, Cohen, Coventry, Coventry, Cully, David Sheffield, de Godoy, De Godoy, Eiser, Emery, Gift, Healthcare Commission, Hynninen, Jacobs, Karadag, Kunik, Kunik, Lacasse, Lamers, Lisansky, Lolak, Miravitlles, Moullec, Narsavage, National Institute for Clinical Excellence, Norweg, Oakley, Peytremann-Bridevaux, Pull, Punekar, Pye, Ries, Rose, Rosser, Salman, Salvi, Sassi-Dambron, Scherer, Schoo, Sirey, Stanley, Sutton, van Ede, Wagena, Wu, Yohannes   +47 more
core   +2 more sources

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Risk of Coronary Heart Disease in People with Chronic Obstructive Pulmonary Disease: A Meta-Analysis

International Journal of COPD, 2021
Jia-Jie Wang Medical College, Soochow University, Suzhou, Jiangsu Province, People’s Republic of ChinaCorrespondence: Jia-Jie WangMedical College, Soochow University, No.
Wang JJ
doaj  

COPD and cardiovascular disease [PDF]

, 2019
COPD is one of the major public health problems in people aged 40 years or above. It is currently the 4th leading cause of death in the world and projected to be the 3rd leading cause of death by 2020.
André, S., Areias, Vanda, Boléo-Tomé, J.P., Cardoso, J., Conde, B., Fragoso, E.   +5 more
core   +3 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Clinical and fiberoptic endoscopic assessment of swallowing in patients with chronic obstructive pulmonary disease

International Archives of Otorhinolaryngology, 2013
Summary Introduction: Chronic obstructive pulmonary disease is characterized by progressive and partially reversible obstruction of pulmonary airflow.
Marina Rodrigues Bueno Macri, Jair Mendes Marques, Rosane Sampaio Santos, Ana Maria Furkim, Irinei Melek, Daniel Rispoli, Maria Cristina de Alencar Nunes   +6 more
doaj   +1 more source

Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease [PDF]

, 2010
Background Combination therapy (inhaled corticosteroids and long-acting beta(2)-agonists) and tiotropium are both used in the treatment of chronic obstructive pulmonary disease (COPD).
Appleton, Appleton, Appleton, Barr, Bateman, Calverley, Effing, Jones, Karner, Keene, Kesten, Lacasse, Nannini, Nannini, Nannini, Singh, Singh, Suissa, Suissa, Tashkin, Yang   +20 more
core   +1 more source

Chronic obstructive pulmonary disease: management of chronic disease [PDF]

Medicine, 2012
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, affecting an estimated 3 million people in the UK. The most common cause is tobacco smoke. Patients with COPD experience a high symptom burden, worsened during disease instability (termed exacerbations or ‘lung attacks’), and a multidisciplinary approach should ...
Russell, R, Norcliffe, J, Bafadhel, M
openaire   +4 more sources

Pulmonary hypertension in chronic obstructive pulmonary disease [PDF]

British Journal of Pharmacology, 2020
Even mild pulmonary hypertension (PH) is associated with increased mortality and morbidity in patients with chronic obstructive pulmonary disease (COPD). However, the underlying mechanisms remain elusive; therefore, specific and efficient treatment options are not available.
Gredic, Marija, Blanco, Isabel, Kovacs, Gabor, Helyes, Zsuzsanna, Ferdinandy, Péter, Olschewski, Horst, Barberà, Joan Albert, Weissmann, Norbert, Justus Liebig University Giessen   +8 more
openaire   +4 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source