Results 71 to 80 of about 1,412,546 (392)

Molecular Simulations of Polymer‐based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release

Advanced Healthcare Materials, EarlyView.
Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao, Xin Jiang, Jinyu Li, Julien Nicolas, Tâp Ha‐Duong   +4 more
wiley   +1 more source

Current status of diagnosis and treatment of pulmonary hypertension in Chinese tertiary hospitals: A nationwide survey

Pulmonary Circulation, 2023
We intended to evaluate the diagnosis and treatment status of pulmonary hypertension (PH) in China and provide the basis for the design of the Chinese PH centers system.
Meng Zhang, Wanmu Xie, Yao Xiao, Wei Guo, Yan Wang, Wenmei Zhang, Shengchen Duan, Qian Gao, Shuai Zhang, Yunxia Zhang, Xueran Guo, Ao Yin, Jiafei Peng, Jun Wan, Zhenguo Zhai, Group of Pulmonary Embolism and Pulmonary Vascular Disease, Chinese Thoracic Society; Working Committee of Pulmonary Embolism and Pulmonary Vascular Disease, Chinese Association of Chest Physicians; Expert Committee, National Project of Standardized Diagnosis and Treatment of Pulmonary Hypertension   +15 more
doaj   +1 more source

Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability.

New England Journal of Medicine, 2019
BACKGROUND Retrospective analyses suggest that pulmonary embolism is ruled out by a d-dimer level of less than 1000 ng per milliliter in patients with a low clinical pretest probability (C-PTP) and by a d-dimer level of less than 500 ng per milliliter in
C. Kearon, Kerstin de Wit, S. Parpia, S. Schulman, M. Afilalo, A. Hirsch, F. Spencer, Sangita Sharma, Frédérick D’Aragon, J. Deshaies, G. Le Gal, A. Lazo-Langner, Cynthia Wu, L. Rudd-Scott, S. Bates, J. Julian   +15 more
semanticscholar   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source

Dicumarol [PDF]

, 1945
Thesis (M.D.)--Boston ...
Steel, Robert MacDonald
core  

MRI of the lung (3/3)-current applications and future perspectives [PDF]

, 2011
BACKGROUND: MRI of the lung is recommended in a number of clinical indications. Having a non-radiation alternative is particularly attractive in children and young subjects, or pregnant women.
A Hebestreit, A Kluge, A Kluge, A Kluge, AA Bankier, AC Henderson, AS Brody, BJ Pichler, BJ Pichler, C Fink, C Hintze, C Hintze, C Rieger, CA Yi, CA Yi, CP Heussel, DM Mannino, F Molinari, F Risse, F Santamaria, G Antoch, G Antoch, G Bauman, G Bauman, G Lutterbey, G Lutterbey, G Sergiacomi, H Hatabu, H Zaidi, HF Wehrl, HK Song, HK Song, IL Theissen, J Biederer, J Biederer, J Biederer, J Biederer, J Biederer, J Biederer, J Biederer, J Ley-Zaporozhan, J Ley-Zaporozhan, JC Hogg, K Cederlund, K Sandek, K Suga, K Suga, LP Qi, M Bhalla, M Decramer, M Eichinger, M Gaeta, M Oudkerk, M Puderbach, M Puderbach, M Puderbach, M Puderbach, M Stern, M Wagner, MD Cohen, ND Abolmaali, NJ Morrison, NL Müller, O Ratib, PA Jong de, PA Jong de, PD Stein, PD Stein, R Eibel, R Failo, RE Jacob, RG McFadden, RJ Theilmann, RL Gibson, S Akata, S Montella, S Pauls, SK Alford, T Amundsen, T Iwasawa, T Iwasawa, T Iwasawa, T Mori, T Rupprecht, TA Kuder, TH Helbich, US Euler, V Peltola, W Hirsch, W Lin, Y Berthezène, Y Ohba, Y Ohno, Y Ohno, Y Ohno, Y Ohno, Y Shao   +96 more
core   +1 more source

Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium

Clinical and applied thrombosis/hemostasis, 2019
Pulmonary embolism (PE) is a life-threatening condition and a leading cause of morbidity and mortality. There have been many advances in the field of PE in the last few years, requiring a careful assessment of their impact on patient care.
B. Rivera-Lebron, M. McDaniel, K. Ahrar, A. Alrifai, D. Dudzinski, Christina L. Fanola, D. Blais, D. Janicke, Roman Melamed, K. Mohrien, E. Rozycki, C. Ross, A. Klein, Parth M Rali, Nicholas R. Teman, Leoara Yarboro, Eugene Ichinose, Aditya M. Sharma, J. Bartos, Mahir D Elder, B. Keeling, H. Palevsky, S. Naydenov, Parijat Sen, N. Amoroso, J. Rodriguez-Lopez, G. Davis, R. Rosovsky, K. Rosenfield, C. Kabrhel, J. Horowitz, Jay S. Giri, V. Tapson, R. Channick   +33 more
semanticscholar   +1 more source

Pulmonary Embolism and Increased Levels of D-Dimer in Patients with Coronavirus Disease

Emerging Infectious Diseases, 2020
We report 3 patients with coronavirus disease who had a decline in respiratory status during their hospital course that responded well to intravenous steroids and interleukin-6 receptor antagonist therapy.
D. Griffin, A. Jensen, Mushmoom Khan, Jessica Chin, Kelly Chin, J. Saad, Ryan Parnell, Christopher Awwad, Darshan Patel   +8 more
semanticscholar   +1 more source

The Space Within: How Architected Voids Promote Tissue Formation

Advanced Materials, EarlyView.
This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou, Isabel B. Hui, Carla Fernandez‐Rico, Marcy Zenobi‐Wong   +3 more
wiley   +1 more source