Results 71 to 80 of about 1,389,478 (387)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Syncope in Elderly People: A Threatening Presentation of Pulmonary Embolism: A Case Report [PDF]

, 2015
age. Its prognosis is largely unpredictable, pending the origin of the sudden loss of consciousness. We report a case of an old woman affected by severe chronic heart failure, who died soon after the development of an episode of syncope, which was ...
Bilora, Franca, Lucia, Sarolo, Pomerri, Fabio, Prandoni, Paolo   +3 more
core  

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

Bayes pulmonary embolism assisted-diagnosis: a new expert system for clinical use [PDF]

, 2007
Background: The diagnosis of pulmonary embolism demands flexible decision models, both for the presence of clinical confounders and for the variability of local diagnostic resources.
Antiga, Luca, Bertolini, Guido, Cavuto, Silvio, Luciani, Davide, Miniati, Massimo, Monti, Simonetta, Pistolesi, Massimo   +6 more
core   +3 more sources

Printing Nacre‐Mimetic MXene‐Based E‐Textile Devices for Sensing and Breathing‐Pattern Recognition Using Machine Learning

Advanced Functional Materials, EarlyView.
This study presents a Ti3C2Tx MXene/WPU nacre‐mimetic nanomaterial as a printable ink for direct‐write printing onto textiles‐based sensors. The resulting wearable device demonstrates high sensitivity, biocompatibility, and mechanical strength. Furthermore, NFC‐enabled humidity sensor produces time‐series data, which informs a machine learning ...
Lulu Xu, Wenqing Chen, Qian Li, Rohit Gupta, Biswajoy Bagchi, Laurence B. Lovat, Manish K. Tiwari   +6 more
wiley   +1 more source

Current status of diagnosis and treatment of pulmonary hypertension in Chinese tertiary hospitals: A nationwide survey

Pulmonary Circulation, 2023
We intended to evaluate the diagnosis and treatment status of pulmonary hypertension (PH) in China and provide the basis for the design of the Chinese PH centers system.
Meng Zhang, Wanmu Xie, Yao Xiao, Wei Guo, Yan Wang, Wenmei Zhang, Shengchen Duan, Qian Gao, Shuai Zhang, Yunxia Zhang, Xueran Guo, Ao Yin, Jiafei Peng, Jun Wan, Zhenguo Zhai, Group of Pulmonary Embolism and Pulmonary Vascular Disease, Chinese Thoracic Society; Working Committee of Pulmonary Embolism and Pulmonary Vascular Disease, Chinese Association of Chest Physicians; Expert Committee, National Project of Standardized Diagnosis and Treatment of Pulmonary Hypertension   +15 more
doaj   +1 more source

Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis [PDF]

, 2002
Hormone replacement therapy (HRT) increases the risk of venous thrombosis. We investigated whether this risk is affected by carriership of hereditary prothrombotic abnormalities.
A. Rumley, Anderson, Bloemenkamp, Daly, E. Daly, F. M. Helmerhorst, F. R. Rosendaal, G. D. O. Lowe, Grady, Grodstein, Hulley, Jick, Kniffin, Lowe, M. Vessey, M. Woodward, Mehta, Nordström, Oger, Rees, Rosendaal, Rosendaal, Silverstein, Stadel, Vandenbroucke, Vessey, Woolf   +26 more
core   +1 more source

Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability.

New England Journal of Medicine, 2019
BACKGROUND Retrospective analyses suggest that pulmonary embolism is ruled out by a d-dimer level of less than 1000 ng per milliliter in patients with a low clinical pretest probability (C-PTP) and by a d-dimer level of less than 500 ng per milliliter in
C. Kearon, Kerstin de Wit, S. Parpia, S. Schulman, M. Afilalo, A. Hirsch, F. Spencer, Sangita Sharma, Frédérick D’Aragon, J. Deshaies, G. Le Gal, A. Lazo-Langner, Cynthia Wu, L. Rudd-Scott, S. Bates, J. Julian   +15 more
semanticscholar   +1 more source

Integrin β4‐Enriched Small Extracellular Vesicle as Drug Delivery Vehicle for Targeting Pulmonary Metastasis of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
The expression of integrin β4 (ITGβ4) on small extracellular vesicle (sEV) correlates with lung‐tropism. Enrichment of ITGβ4 on sEVs enhances their lung‐targeting ability. The sEVs loaded with doxorubicin exhibit superior therapeutic efficacy in a lung metastasis mouse model.
Tung Him Ng, Aijun Liang, Maximus CF Yeung, Sze Keong Tey, Kam‐Leung Siu, Sin‐Yee Fung, Dong‐Yan Jin, Judy Wai Ping Yam   +7 more
wiley   +1 more source