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Pulmonary fibrosis

Histopathology, 1990
Diffuse interstitial pulmonary fibrosis is the end result of alveolar damage which may occur as a sudden acute incident or as a slowly developing process. Potentiating factors include release of enzymes and generation of oxygen radicals by granulocytes.
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Endothelin in Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology, 2011
The endothelin receptor-ligand system includes a family of polypeptides and G-protein-coupled receptors, which, in addition to their classic activity in the regulation of vascular tone (both directly and through the control of nitric oxide), were implicated in a wide variety of other key biological processes.
Elisabetta A. Renzoni   +2 more
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Genetics of Pulmonary Fibrosis

Seminars in Respiratory and Critical Care Medicine, 2003
Identifying genetic determinants of pulmonary fibrosis is at an early stage of evolution. It is now well recognized that "pulmonary fibrosis" covers a broad range of lung diseases including most topically the idiopathic interstitial pneumonias that have been classified recently.
R. M. du Bois   +2 more
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Idiopathic Pulmonary Fibrosis

Journal of Thoracic Imaging, 2016
Idiopathic pulmonary fibrosis (IPF) is the most common fibrosing lung disease and is associated with a very poor prognosis. IPF manifests histopathologically as usual interstitial pneumonia (UIP) and as subpleural and basal predominant reticulation with honeycombing on high-resolution computed tomography (HRCT) of the chest.
Maria D. Martin   +2 more
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Idiopathic Pulmonary Fibrosis

New England Journal of Medicine, 2001
Idiopathic pulmonary fibrosis is a rapidly progressive illness of unknown cause characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease. Treatment at present remains largely supportive, with evidence that patients' satisfaction and survival may be improved by referral to centers specializing in the evaluation ...
Thomas J. Gross, Gary W. Hunninghake
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Pulmonary Emphysema and Fibrosis

Diseases of the Chest, 1953
1)Thirty-seven patients with pulmonary emphysema and/or fibrosis have been reviewed. The outstanding symptoms are dyspnea, cyanosis and cough. The main findings on examination are barrel-shaped chest with limited respiratory excursion, hyper-resonance on percussion, hypertrophy of the auxiliary respiratory muscles and decreased pulmonary function ...
James E. O'hare   +3 more
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Diffuse Pulmonary Fibrosis

Postgraduate Medicine, 1959
Diffuse pulmonary fibrosis may have many different causes. When roentgenographs examination reveals evidence of this disease, a detailed history should be obtained and a careful physical examination performed. Extensive laboratory procedures often are necessary. Prognosis and treatment depend on the underlying cause and on complications.
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Idiopathic Pulmonary Fibrosis

Seminars in Respiratory and Critical Care Medicine, 2012
Idiopathic pulmonary fibrosis (IPF) is a specific form of progressive, chronic fibrosing interstitial lung disease occurring primarily in older adults and limited to the lungs. The prognosis is dire, with half of all patients progressing to death from respiratory failure within 3 to 5 years from initial diagnosis. The pathogenesis of IPF is complex and
Jessica M. Adkins, Harold R. Collard
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Idiopathic pulmonary fibrosis

Current Opinion in Pulmonary Medicine, 1996
Idiopathic pulmonary fibrosis (IPF), or cryptogenic fibrosing alveolitis as it is known in the United Kingdom and Europe, is perhaps one of the most complex and frustrating pulmonary disorders. The cause of this illness is unknown. Treatment often founders in a mire of discontent, dissatisfaction, and failure. In fact, the philosophic homily "If you do
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Overview of Pulmonary Fibrosis*

Chest, 2002
Pulmonary fibrosis is a component of over 200 interstitial lung diseases. Some have known etiologies, however, for many diseases, the etiology remains unknown or obscure. This brief review examines the prevalence and classification of these diseases, the approach to be taken for the investigation of a patient suspected of having pulmonary fibrosis, the
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