Results 61 to 70 of about 6,384,497 (302)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Noninvasive screening for surgery in adults with simple shunting congenital heart disease

BMC Cardiovascular Disorders
Objectives The aim of this study was to use non-invasive parameters to assess eligibility to undergo surgery in patients with adult congenital heart disease (CHD).
Xingxing Sun, Yang Chen, Jianhua Xu, Hongyu Gao, Hanqing Zhu, Bigyan Pudasaini, Wenlan Yang, Yuan Cao, Jian Guo   +8 more
doaj   +1 more source

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]

, 2011
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Königshoff, M., Melanie Königshoff, Königshoff, Melanie   +2 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Coaching patients during pulmonary function testing: A practical guide [PDF]

, 2015
Pulmonary function testing is a cornerstone in the diagnosis and management of individuals with respiratory disease. However, correct interpretation of pulmonary function data relies heavily on acceptable test quality, which in turn is dependent on ...
Heidi J Cheung, Lawrence Cheung
core  

Application of [18F]FLT‐PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type 2 mutation carriers [PDF]

, 2021
Pulmonary arterial hypertension is a heterogeneous group of diseases characterized by vascular cell proliferation leading to pulmonary vascular remodelling and ultimately right heart failure. Previous data indicated that 3′‐deoxy‐3′‐[18F]‐fluorothymidine
Onno A. Spruijt, Jansen, Samara MA, Anton V. Noordegraaf, Botros, Liza, Liza Botros, Ashek, Ali, de Man, Frances S, Bogaard, Harm J., Marc C. Huisman, Tramper, Jelco, Spruijt, Onno A., Harms, Hans, Jelco Tramper, Samara M.A. Jansen, Jansen, Samara M. A., Hans Harms, Anton Vonk Noordegraaf, Harm J. Bogaard, de Man, Frances S., Bogaard, Harm J, Zhao, Lan, Aman, Jurjan, Ali Ashek, Frances S. de Man, Frances S. deMan, Noordegraaf, Anton V., Spruijt, Onno A, Huisman, Marc C., Huisman, Marc C, Lan Zhao, Noordegraaf, Anton, Jurjan Aman   +31 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Clinical Usefulness of Response Profiles to Rapidly Incremental Cardiopulmonary Exercise Testing

Pulmonary Medicine, 2013
The advent of microprocessed “metabolic carts” and rapidly incremental protocols greatly expanded the clinical applications of cardiopulmonary exercise testing (CPET).
Roberta P. Ramos, Maria Clara N. Alencar, Erika Treptow, Flávio Arbex, Eloara M. V. Ferreira, J. Alberto Neder   +5 more
doaj   +1 more source

What Are the Effects of Electronic Cigarettes on Lung Function Compared to Non-Electronic Cigarettes? A Systematic Analysis

International Journal of Public Health, 2022
Objective: The effects of e-cigarettes on lung function were compared between the e-cigarette and the non-e-cigarette group, as well as self-changes after inhaling e-cigarettes.Method: From March 1st, 2022, relevant literature was selected from four ...
Yumeng Song, Xin Li, Chaoxiu Li, Shuang Xu, Yong Liu, Yong Liu, Xiaomei Wu   +6 more
doaj   +1 more source