Results 291 to 300 of about 1,035,671 (315)

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

open access: yesAdvanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang   +9 more
wiley   +1 more source

Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine

open access: yesAdvanced Science, EarlyView.
A personalized whole tumor cell vaccine (FAST) is developed to address immunosuppressive tumor microenvironments and genomic instability‐driven heterogeneity. Irradiation and cryoablation‐treated tumor cells generate fragmented antigens (FAs) that activate broad‐spectrum antigen presentation via upregulated immunogenic cell death, MHC‐I, and damage ...
Yuan Li   +14 more
wiley   +1 more source

Comparison of Clinical Scores for Predicting Stroke‐Associated Pneumonia After Acute Ischemic Stroke

open access: yesAGING MEDICINE, EarlyView.
Our study compared the discrimination and calibration of the Kwon Pneumonia Score, A2DS2 score, PANTHERIS score, AIS‐APS score, ISAN score, and PASS score in SAP identification; of these, the AIS‐APS score showed the best performance. ABSTRACT Objectives To compare the discrimination and calibration of six risk scoring systems in the assessment of ...
Linlin Wang   +8 more
wiley   +1 more source

Risk Factors and Predictive Models for Sarcopenia in Older Adults

open access: yesAGING MEDICINE, EarlyView.
Independent risk factors for sarcopenia identified by Lasso regression and logistic regression in the study were BMI, prealbumin, albumin/globulin ratio (A/G ratio), serum creatinine, and phosphorus. These factors were used to construct a nomogram model and a decision tree model. Both models showed effectiveness in predicting sarcopenia in older adults,
Shiyuan Zhang   +9 more
wiley   +1 more source

Factors Associated With Anxiety Symptoms in Older Adults Attending an Outpatient Geriatric Service: A Cross‐Sectional Study

open access: yesAGING MEDICINE, EarlyView.
An analytical study was carried out by secondary analysis of a database of a study performed between 2010 and 2015 at the Naval Medical Center of Peru (CEMENA). the analysis revealed that depressive symptoms, polypharmacy, slow gait speed, education, and marital status were significant contributors to anxiety in this population.
Gianella Grajeda‐León   +7 more
wiley   +1 more source
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