Results 71 to 80 of about 428,889 (351)

Point-of-care versus central testing of hemoglobin during large volume blood transfusion. [PDF]

, 2019
BACKGROUND: Point-of-care (POC) hemoglobin testing has the potential to revolutionize massive transfusion strategies. No prior studies have compared POC and central laboratory testing of hemoglobin in patients undergoing massive transfusions. METHODS: We
Awsare, Bharat K., Baram, Michael, Crittendon, Denine, Evans, Lilah, Goldsmith, Barbara, Harach, Mary, Herman, Justin, Karp, Julie, LaNoue, Marianna, Park, Brian, Peedin, Alexis R., Warnick, Eugene P., West, Frances Mae   +12 more
core   +2 more sources

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Swimming-induced changes in pulmonary function: special observations for clinical testing

BMC Sports Science, Medicine and Rehabilitation, 2021
Background A special improvement in pulmonary function is found in swimmers. In clinical testing the airway reactivity is observed at certain exercise intensity and target ventilation. However, in highly trained swimmers exercising in water the reactions
Marja Päivinen, Kari Keskinen, Heikki Tikkanen   +2 more
doaj   +1 more source

Physiological and clinical consequences of relief of right ventricular outflow tract obstruction late after repair of congenital heart defects. [PDF]

, 2006
BACKGROUND: Right ventricular outflow tract obstruction (RVOTO) is a common problem after repair of congenital heart disease. Percutaneous pulmonary valve implantation (PPVI) can treat this condition without consequent pulmonary regurgitation or ...
Bonhoeffer, P, Coats, L, Deanfield, JE, Derrick, G, Jones, R, Khambadkone, S, Mist, B, Pellerin, D, Schievano, S, Sridharan, S, Taylor, AM   +10 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Age, gender, and pulmonary diseases in compliance with pulmonary function testing

Medicine Science
Pulmonary function tests (PFTs) are critical tools for the diagnosis and monitoring of respiratory diseases. However, patient compliance with the test affects the reliability of the results. This study was designed to analyze factors such as age, gender,
Maside Ari, Berna Akinci Ozyurek, Omer Faruk Tuten, Esma Dolmus, Tunahan Dolmus   +4 more
doaj   +1 more source

Design and Benchmark Testing for Open Architecture Reconfigurable Mobile Spirometer and Exhaled Breath Monitor with GPS and Data Telemetry. [PDF]

, 2019
Portable and wearable medical instruments are poised to play an increasingly important role in health monitoring. Mobile spirometers are available commercially, and are used to monitor patients with advanced lung disease.
Davis, Cristina E, Delplanque, Jean Pierre, Duong, Theresa N, Fung, Alexander G, Kenyon, Nicholas J, Littlefield, Leslie, Schivo, Michael, Tan, Laren D   +7 more
core   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Assessment of fitness and exercise tolerance of chronic obstructive pulmonary disease patients in correlation with their lifestyle

The Egyptian Journal of Bronchology, 2016
Background Chronic obstructive pulmonary disease (COPD) is a progressive, chronic disease in which the patient’s nutritional status is critical for optimizing outcomes. Pulmonary system abnormalities certainly limit exercise in patients with COPD. Aim of
Mohammad A. E. Faramawy, Emad E. A. Korraa, Ibrahim A. Dwedar, Nermine M. Riad, Mohammed A. M. Nada   +4 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source