Results 31 to 40 of about 350,009 (265)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of pranayama on pulmonary functions and heart rate variability in patients with mild-to-moderate persistent bronchial asthma

National Journal of Physiology, Pharmacy and Pharmacology
Background: The global burden of bronchial asthma is on the rise. Asthma is a disorder of airflow obstruction associated with deranged pulmonary functions and autonomic imbalance.
Debdeep Saha, Dhanalakshmi Yerrabelli, Pravati Pal, Manju R, Jothi Marie Feula, Karthika Priyadarshini U, Nagalakshmi Tallam   +6 more
doaj   +1 more source

Pulmonary function tests in nonsmoking auto rickshaw drivers [PDF]

Al Ameen Journal of Medical Sciences, 2014
Background: Rapid urbanization, industrialization and increase in number of vehicles is aggravating environmental pollution. Continuous exposure to automobile exhaust has been shown to affect functioning of different systems of the body.
Ibrahim Farooque, Srinivasa Jayachandra
doaj  

Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children

Respiratory Medicine Case Reports, 2021
Background: There is strong evidence for a causal relationship between helminthes infection and allergic disease like asthma due to the similarity in the way they respond.
Suha Haithem Mohammed, Azza Sajid Jabbr, Nawal Khalil Ibrahim   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Pulmonary function tests in ulcerative colitis

Journal of Research in Medical Sciences, 2014
Background: Pulmonary impairment in patients suffering ulcerative colitis (UC) has been suggested by several investigators using standard pulmonary function tests (PFTs).
Babak Amra, Ghazal Ataabadi, Mohamad Hassan Emami, Akbar Hassanzadeh, Mohammad Golshan, Forogh Soltaninejad   +5 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Total antioxidant capacity as a marker in predicting severity of chronic obstructive pulmonary diseases

The Egyptian Journal of Bronchology, 2017
Background The pathogenesis of chronic obstructive pulmonary disease (COPD) is multifactorial; oxidative stress is suggested to be one of the pathogenetic factors.
Ragaa H. M. Salama, Maha M. Elkholy, Samiaa Hamdy Sadek, Israa G. Mahdy   +3 more
doaj   +1 more source

Lung function disorders among sickle cell disease patients in Basra City, Iraq

Iraqi Journal of Pharmaceutical Sciences, 2023
Background: In sickle cell disease (SCD), lung function impairments might be obstructive, restrictive, or both. Due to a lack of extensive epidemiological investigations, the exact prevalence of sickle cell chronic lung illnesses and the way to identify
Azza Sajid, Abeer Mohammed, Nawal Ibrahim   +2 more
doaj   +1 more source