Results 141 to 150 of about 2,498,926 (399)
Advanced Science, EarlyView.A novel modified SIRT6 variant (dSIRT6) H133Y‐mediated enrichment technique unmasks 15 new human lysine‐myristoylated proteins. Notably, Sirtuin 6 (SIRT6) demyristoylation of activating transcription factor 2 (ATF2) at K296 orchestrates its nucleoplasmic translocation.
Runyang Feng +40 more
wiley +1 more source
The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation [PDF]
, 2016 Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT+) in mice results in an estrogen-
Anagnostopoulou, Aikaterini +9 more
core +1 more source
Could pulmonary arterial hypertension patients be at a lower risk from severe COVID-19?
Pulmonary Circulation, 2020 Evelyn M. Horn, Murali Chakinala, Ronald Oudiz, Elizabeth Joseloff and Erika B. Rosenzweig Advanced Heart Failure & Pulmonary Vascular Disease Programs, Weill Cornell Medicine, New York Presbyterian Hospital, New York, USA; Division of Pulmonary ...
E. Horn +4 more
semanticscholar +1 more source
Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Advanced Science, EarlyView.Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan +12 more
wiley +1 more source
Pulmonary CirculationThe aim of this single‐centre retrospective observational study was to evaluate the safety, tolerability, and efficacy of an in‐class combination therapy switch from bosentan plus sildenafil to ambrisentan plus tadalafil in children with pulmonary ...
Cara Morgan +7 more
doaj +1 more source
Persistent Vascular Collagen Accumulation Alters Hemodynamic Recovery from Chronic Hypoxia [PDF]
, 2012 Pulmonary arterial hypertension (PAH) is caused by narrowing and stiffening of the pulmonary arteries that increase pulmonary vascular impedance (PVZ). In particular, small arteries narrow and large arteries stiffen. Large pulmonary artery (PA) stiffness
Chesler, Naomi C. +5 more
core +2 more sources
Risk stratification and medical therapy of pulmonary arterial hypertension
European Respiratory Journal, 2019 Pulmonary arterial hypertension (PAH) remains a severe clinical condition despite the availability over the past 15 years of multiple drugs interfering with the endothelin, nitric oxide and prostacyclin pathways.
N. Galiè +10 more
semanticscholar +1 more source
Advanced Science, EarlyView.Shear‐activated nanoparticles carrying nitroglycerin selectively target high‐shear stress collateral vessels during ischaemic stroke, enhancing blood flow to at‐risk brain without systemic side effects. This novel approach significantly improves outcomes in animal models, outperforming conventional nitroglycerin delivery.
Magdalena Litman +21 more
wiley +1 more source
Scientific ReportsTargeted vasopeptide therapies have significantly advanced the management of pulmonary arterial hypertension (PAH). However, due to insufficient preclinical evidence regarding the involvement of the endothelin-1 (ET-1) pathway in chronic thromboembolic ...
Benchenouf Feriel +16 more
doaj +1 more source
Sarcopenia in Patients with Chronic Thromboembolic Pulmonary Hypertension
Journal of Cardiovascular Development and DiseaseBackground: Sarcopenia, or loss of skeletal muscle mass, has been associated with poor outcomes (e.g., functional decline, increased mortality, and low quality of life), but its role in CTEPH remains unclear.
Steven Hopkins +8 more
doaj +1 more source