Results 111 to 120 of about 164,448 (358)

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt/β-catenin signaling pathway in mice

Ecotoxicology and Environmental Safety, 2022
Polystyrene microplastics (PS-MPs) are emerging pollutants that are absorbed by organisms. Due to their small volume and strong biological permeability, they affect the biological functions of cells.
Xuran Li, Tongtong Zhang, Wenting Lv, Hui Wang, Haoran Chen, Qinghua Xu, Hourong Cai, Jinghong Dai   +7 more
doaj  

Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

Particle and Fibre Toxicology, 2017
Background Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia.
Cécile Vignal, Muriel Pichavant, Laurent Y. Alleman, Madjid Djouina, Florian Dingreville, Esperanza Perdrix, Christophe Waxin, Adil Ouali Alami, Corinne Gower-Rousseau, Pierre Desreumaux, Mathilde Body-Malapel   +10 more
doaj   +1 more source

Btp Proteins from Brucella abortus Modulate the Lung Innate Immune Response to Infection by the Respiratory Route [PDF]

, 2017
Although inhalation of infected aerosols is a frequent route for Brucella infection in humans, it rarely causes pulmonary clinical manifestations, suggesting a mild or nearly absent local inflammatory response.
Baldi, Pablo Cesar, Comerci, Diego José, Falivene, Juliana, Fernandez, Andrea Giselle, Ferrero, Mariana Cristina, Hielpos, María Soledad, Vanzulli, Silvia   +6 more
core   +1 more source

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source

Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine

Advanced Science, EarlyView.
A personalized whole tumor cell vaccine (FAST) is developed to address immunosuppressive tumor microenvironments and genomic instability‐driven heterogeneity. Irradiation and cryoablation‐treated tumor cells generate fragmented antigens (FAs) that activate broad‐spectrum antigen presentation via upregulated immunogenic cell death, MHC‐I, and damage ...
Yuan Li, Huiqin Chen, Qiaofeng Shen, Yingshuang Liu, Pingping Li, Yuqi Ma, Yugang Wang, Shengkai Li, Xueqing Yan, Liyu Liu, Jianwei Shuai, Min Wu, Qi Ouyang, Feng‐Ming (Spring) Kong, Gen Yang   +14 more
wiley   +1 more source

Novel inhalation therapy in pulmonary fibrosis: principles, applications and prospects

Journal of Nanobiotechnology
Pulmonary fibrosis (PF) threatens millions of people worldwide with its irreversible progression. Although the underlying pathogenesis of PF is not fully understood, there is evidence to suggest that the disease can be blocked at various stages ...
Meiling Zheng, Wei Zhu, Fei Gao, Yu Zhuo, Mo Zheng, Guanghao Wu, Cuiling Feng   +6 more
doaj   +1 more source

Particulate Matter Exposure Impairs Systemic Microvascular Endothelium-Dependent Dilation [PDF]

, 2004
Acute exposure to airborne pollutants, such as solid particulate matter (PM), increases the risk of cardiovascular dysfunction, but the mechanisms by which PM evokes systemic effects remain to be identified.
Barger, Mark, Boegehold, Matthew A., Castranova, Vincent, Nurkiewicz, Timothy R., Porter, Dale W.   +4 more
core   +3 more sources

Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation

Advanced Science, EarlyView.
Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen   +3 more
wiley   +1 more source

Health Hazard Manual for Firefighters [PDF]

, 1990
[Excerpt] Firefighters, as well as victims, can be exposed to a variety of toxic substances during a fire. Some of these toxicants are particularly insidious because they are produced by thermal decomposition before smoke makes a fire ...
Brown, Nellie J.
core   +1 more source