Results 161 to 170 of about 2,507 (209)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Endotype Classification of Nonsteroidal Anti‐Inflammatory Drug‐Exacerbated Respiratory Disease According to Chronic Rhinosinusitis Comorbidity

Clinical &Experimental Allergy, EarlyView.
Soyoon Sim, Jieun Seo, Junhyuk Chang, Yoo Seob Shin, Rae Woong Park, Hae‐Sim Park   +5 more
wiley   +1 more source

The Discovery of Inhaled Prostanoids for Pulmonary Hypertension

Pulmonary Circulation
openaire   +3 more sources

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Pulmonary oedema associated with hydrocarbon inhalation

Intensive Care Medicine, 1977
A patient with gross pulmonary oedema secondary to inhalation of paint fumes is described. Treatment with mechanical ventilation and positive end expiratory pressure was required.
Roy D Cane, Buchanan N, Miller M
exaly   +3 more sources

PENICILLIN INHALATION IN PULMONARY DISEASE

Lancet, The, 1946
J H Humphrey
exaly   +3 more sources

Inhaled Therapies for Pulmonary Hypertension

Respiratory Care, 2015
The inhaled route has a number of attractive features for treatment of pulmonary hypertension, including delivery of drug directly to the target organ, thus enhancing pulmonary specificity and reducing systemic adverse effects. It can also improve ventilation/perfusion matching by dilating vessels supplying ventilated regions, thus improving gas ...
Nicholas S, Hill, Ioana R, Preston, Kari E, Roberts   +2 more
openaire   +2 more sources

Milk antibodies in pulmonary inhalation

Journal of Paediatrics and Child Health, 1983
ABSTRACT. To determine the association between inhalation and increased circulating milk antibodies, the presence of milk precipitins and haemagglutinating titres of antibody to casein and lactalbumin were determined in a series of 100 children studied by radionuclide ‘milk scan’and/or barium swallow for possible milk inhalation.
A S, Kemp, P, McVeagh, E, Lo, R, Howman-Giles   +3 more
openaire   +2 more sources

Pulmonary effects of marijuana inhalation

Expert Review of Respiratory Medicine, 2011
Marijuana is the most commonly used illicit drug around the world. It is most often consumed through smoking, placing the respiratory system in direct contact with the toxic constituents of the drug, which are similar to those of tobacco cigarettes. However, accurate study of the adverse effects of marijuana is difficult to perform, owing to marijuana ...
Megan L, Howden, Matthew T, Naughton
openaire   +2 more sources