Results 81 to 90 of about 164,448 (358)
On the Relentless Pursuit of an Oral Insulin Delivery System: How Far is Too Far?
Advanced Therapeutics, EarlyView.Injectable insulin preparations have far outpaced oral ones by virtue of adequate bioavailability and are driven by innovations, including insulin pumps, real‐time blood glucose monitoring, and artificial intelligence. In contrast, oral insulin delivery systems, including nanomedicines, continue to struggle and lag due to varied reasons.
Sourav Bhattacharjee
wiley +1 more source
Particle and Fibre Toxicology, 2023 Background Exposure to micro- and nanoplastic particles (MNPs) in humans is being identified in both the indoor and outdoor environment. Detection of these materials in the air has made inhalation exposure to MNPs a major cause for concern.
Chelsea M Cary +10 more
doaj +1 more source
Pulmonary drug delivery and retention: a computational study to identify plausible parameters based on a coupled airway-mucus flow model [PDF]
arXiv, 2020 Pulmonary drug delivery systems rely on inhalation of drug-laden aerosols produced from aerosol generators such as inhalers, nebulizers etc. On deposition, the drug molecules diffuse in the mucus layer and are also subjected to mucociliary advection which transports the drugs away from the initial deposition site.
arxiv
Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future. [PDF]
, 2017 The respiratory system consists of an integrated network of organs and structures that primarily function for gas exchange. In mammals, oxygen and carbon dioxide are transmitted through a complex respiratory tract, consisting of the nasal passages ...
Miller, Lisa +3 more
core +1 more source
Advanced Science, EarlyView.Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin +15 more
wiley +1 more source
Adults with well‐healed burn injuries have lower pulmonary function values decades after injury
Physiological Reports, 2022 Sub‐acute (e.g., inhalation injury) and/or acute insults sustained during a severe burn injury impairs pulmonary function. However, previous work has not fully characterized pulmonary function in adults with well‐healed burn injuries decades after an ...
Joseph C. Watso +9 more
doaj +1 more source
Pulmonary embolism and oxygen inhalation
Kazan medical journal, 2021 Prof. G. Lotheissen (Zentrbl. F. Chir. No. 41. 1929) saw success from inhalation of oxygen in pulmonary embolism and suggests using it when it is impossible to perform the Trendelenburg operation.
openaire +3 more sources
Review of hypoxaemia in the anaesthetized horse: predisposing factors, consequences and management [PDF]
, 2017 Objectives: To discuss how hypoxaemia might be harmful and why the horse is particularly predisposed to developing it. To review the strategies that are used to manage hypoxaemia in anaesthetised horses, to describe how successful these strategies are
Auckburally, Adam, Nyman, Görel
core +1 more source
Advanced Science, EarlyView.During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu +13 more
wiley +1 more source
Respiratory Research, 2005 Background The aim of the study was to assess the chronic effects of combined phosphodiesterase 3/4 inhibitor tolafentrine, administered by inhalation, during monocrotaline-induced pulmonary arterial hypertension (PAH) in rats. Methods CD rats were given
Weissmann Norbert +9 more
doaj +1 more source