Results 181 to 190 of about 1,534,954 (286)

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Preservation of the right bronchial artery by maintaining the azygos arch during minimally invasive esophagectomy: a two-center retrospective cohort study. [PDF]

J Thorac Dis
Tsuda Y, Nakanoko T, Kimura Y, Natsugoe K, Hu Q, Kawazoe T, Nambara S, Ando K, Ninomiya M, Oki E, Yoshizumi T.   +10 more
europepmc   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Double-Port Totally Endoscopic Mitral Valve Replacement Through a Prosthesis-Sized Working Incision with Posterior Subvalvular Preservation. [PDF]

J Saudi Heart Assoc
Khang CD, Quang TD, Thuan PQ, Minh VN, Chuong PTV, Dinh NH.   +5 more
europepmc   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

A study on the effectiveness of pulmonary flushing for lung preservation

The Journal of the Japanese Association for Chest Surgery, 1991
Tsubota, Noriyuki, Nakamoto, Kembu, Taniguchi, Kiyohide, Nii, Kiyomi, Kawaguchi, Hitoshi, Hayashi, Eiichi, Maeda, Masazumi   +6 more
openaire   +2 more sources

Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems

Advanced Science, EarlyView.
The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan, Mahmoud Tavakoli, Norbert Radacsi, Bee Luan KHOO   +3 more
wiley   +1 more source

Blueberry Extract and Resistance Training in Severe Pulmonary Arterial Hypertension: Effects on Lung and Right-Ventricle Function and Structure. [PDF]

Antioxidants (Basel)
Leite LB, Lopes Soares L, Costa SFF, Guimarães-Ervilha LO, Generoso SCDL, Miranda Xavier MA, Eduardo de Carvalho Quintão A, Faria MS, Iasbik-Lima T, Herter FG, Turck P, da Rosa Araujo AS, Fernandes T, Pelozin BRA, Oliveira EM, Forte P, Machado-Neves M, Reis ECC, Natali AJ.   +18 more
europepmc   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Postnatal Clinical Course in Fetuses Diagnosed with Tetralogy of Fallot and Double-Outlet Right Ventricle with Absent Ductus Arteriosus.

Fetal Diagn Ther
Hayashi K, Ishii Y, Mori M, Matsuo K, Asasda D, Tanimoto K, Kanaya T, Tsumura S, Aoki H.   +8 more
europepmc   +1 more source