Results 41 to 50 of about 1,534,954 (286)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Iron-Dependent Mitochondrial Dysfunction Contributes to the Pathogenesis of Pulmonary Fibrosis

Frontiers in Pharmacology, 2022
Although the pathogenesis of pulmonary fibrosis remains unclear, it is known to involve epithelial injury and epithelial-mesenchymal transformation (EMT) as a consequence of cigarette smoke (CS) exposure.
Mai Takahashi, Kenji Mizumura, Yasuhiro Gon, Tetsuo Shimizu, Yutaka Kozu, Sotaro Shikano, Yuko Iida, Mari Hikichi, Shinichi Okamoto, Kota Tsuya, Asami Fukuda, Shiho Yamada, Kaori Soda, Shu Hashimoto, Shuichiro Maruoka   +14 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A desferoxamina e seu efeito protetor na preservação pulmonar Desferoxamine and its protective effect in pulmonary preservation

Brazilian Journal of Cardiovascular Surgery, 1989
Há recentes evidências de que radicais livres derivados do oxigênio estáo envolvidos na lesão tecidual decorrente de isquemia e subseqüente reperfusão. A desferoxamina (DF), evitando a produção de radicais hidroxila e eliminando o ânion superóxido, pode ...
Luiz Sérgio Fragomeni, Robert S Bonser, Brian Edwards, Stuard W Jamieson, Michael P Kaye   +4 more
doaj  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Robotic esophagectomy with function‐preserving radical mediastinal lymphadenectomy for esophageal cancer

Annals of Gastroenterological Surgery
Radical lymphadenectomy is the critical component of surgery for esophageal cancer. However, lymphadenectomy significantly contributes to postoperative morbidity, particularly in terms of pulmonary complications following esophagectomy.
Raja Kalayarasan, Pothugunta Sai Krishna
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Clinical Case of Successful Surgical Correction of Tetralogy of Fallot by Using the Right Atrial Appendage as a Neopulmonary Valve [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Tetralogy of Fallot (TOF) is one of the common cardiac malformation with depletion of the pulmonary circulation. In the long term, preservation of neopulmonary bicuspid valve function in Tetralogy of Fallot has a key value in pediatric cardiac surgery ...
Bakhytzhan Nurkeyev, Shukhrat Marassulov, Yerbol Aldabergenov, Akkerbez Adilbekova, Saniya Murzabayeva, Elmira Kuandykova, Asiya Akhmoldaeva   +6 more
doaj   +1 more source