Results 131 to 140 of about 1,404,214 (346)

Pulmonary‐Targeted Nanoparticles Interrupt the Malignant Mechanical and Biochemical Signaling Crosstalk for Idiopathic Pulmonary Fibrosis Therapy

Advanced Science, EarlyView.
Idiopathic pulmonary fibrosis (IPF) progression is driven by TGF‐β induced biochemical signals and mechanical signals from increased ECM stiffness. Pulmonary‐targeted VB‐RT NPs not only eliminate excessive ROS and penetrate the dense ECM collagen barrier via NO release, but also simultaneously interrupt the persistent malignant between mechanical and ...
Xue‐Na Li, Ya‐Ping Lin, Xi‐Xi Ma, Yue‐Fei Fang, Hui Wang, Chun‐Hui Cui, Chen Zhang, Jin‐You Piao, Jee‐Heon Jeong, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +11 more
wiley   +1 more source

Molecular, Subcellular and Cellular Pathogenesis Mechanisms of Tuberculous Pneumonia [PDF]

Саратовский научно-медицинский журнал, 2009
Pathogenesis mechanisms of tuberculosis have been considered. It is shown, that important place in pulmonary tuberculosis therapy should belong to the means of pathogenetic therapy directed to the improvement of pulmonary circulation and living ...
V.V. Yerokhin
doaj  

Pulmonary Distribution and Efficacy of Exogenous Surfactant in Lung-Lavaged Rabbits Are Influenced by the Instillation Technique [PDF]

, 1993
Hugo Segerer, Warry van Gelder, Franz W M Angenent, Léon J. P. M. van Woerkens, Tore Curstedt, Michael Obladen, Burkhard Lachmann   +6 more
openalex   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome [PDF]

, 2016
Indexación: Web of Science; Pub Med CentralExtracorporeal membrane oxygenation (ECMO) is increasingly being used to treat severe acute respiratory distress syndrome (ARDS).
Alegría, Leyla, Amthauer, Macarena, Araos, Joaquín, Bruhn, Alejandro, Bugedo, Guillermo, Carreño, Pamela, Castro, Gabriel, Cruces, Pablo, Damiani, Felipe, Erranz, Benjamín, García, Patricio, Medina, Tania, Retamal, Jaime, Rodriguez, Felipe, Salomon, Tatiana, Soto, Dagoberto, Tapia, Pablo   +16 more
core  

Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein. [PDF]

, 1990
Jonathan R. Wispé, J. C. Clark, Barbara Warner, Dianora Fajardo, William E. Hull, Ronald B. Holtzman, Jeffrey A. Whitsett   +6 more
openalex   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Biophysical, Structural and Compositional characterization at the molecular level of Native Pulmonary Surfactant Membranes directly isolated from mice Wild-type and Knocked-out Protein D Bronco-alveolar Lavage Fluid [PDF]

, 2009
Jorge Bernardino de la Serna, Søren Hansen, Hans Kristian Hannibal‐Bach, Adam Cohen Simonsen, Jens Knudsen, Luís A. Bagatolli   +5 more
openalex   +1 more source

Light Metabolically Reprograms CD8+ T Cells to Potentiate STING‐Driven Tumor Eradication and Prevent Metastasis

Advanced Science, EarlyView.
Low‐level light (LLL) rejuvenates exhausted CD8+ T cells, boosting STING‐driven tumor eradication and prevents metastasis. NanoSTING@Mn enhances CD8+ T cells infiltration while LLL restores its function expanding to progenitor‐exhausted cells. These cells form central memory T cells in lymphoid organs. Intranasal nanoSTING@Mn redirects antitumor CD8+ T
Asmita Banstola, Shilin Gao, Zhengkung Zhang, Yan Dong, Prabhat Upadhyay, Quanwei Zhang, Yongli Li, Zuan‐Tao Lin, Zhilong Wang, Mei X. Wu   +9 more
wiley   +1 more source

An amphipathic helical motif common to tumourolytic polypeptide NK‐lysin and pulmonary surfactant polypeptide SP‐B [PDF]

, 1995
Mats Andersson, Tore Curstedt, Hans Jörnvall, Jan Johansson   +3 more
openalex   +1 more source