Results 301 to 310 of about 74,761 (355)
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Annual Review of Medicine, 1989
Pulmonary surfactant is a chemically heterogeneous material that provides a stable, low surface tension within the lung, thereby preventing alveolar collapse at low transpulmonary pressures. Both the lipid and the protein components of surfactant are important for establishing and maintaining a low surface tension.
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Pulmonary surfactant is a chemically heterogeneous material that provides a stable, low surface tension within the lung, thereby preventing alveolar collapse at low transpulmonary pressures. Both the lipid and the protein components of surfactant are important for establishing and maintaining a low surface tension.
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Pulmonary Surfactant Metabolism
Clinics in Chest Medicine, 1989Recent work suggests that surfactant undergoes a complex sequence of metabolic events during its life cycle in the alveolar airspace. The composition, turnover, and metabolism of surfactant, and the possible "control points" in its metabolic pathway that might be compromised in disease states are discussed.
Samuel Hawgood, J. R. Wright
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Journal of Applied Physiology, 1982
Pulmonary surfactant reduces the surface tension of the alveolar air-liquid interface, thereby providing mechanical stability and preventing alveolar atelectasis. More than 50% of surfactant is dipalmitoyl phosphatidylcholine, a material that is capable of reducing the surface tension of the alveolar interface to uniquely low values.
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Pulmonary surfactant reduces the surface tension of the alveolar air-liquid interface, thereby providing mechanical stability and preventing alveolar atelectasis. More than 50% of surfactant is dipalmitoyl phosphatidylcholine, a material that is capable of reducing the surface tension of the alveolar interface to uniquely low values.
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Pulmonary surfactant protein A isolation as a by‐product of porcine pulmonary surfactant production
Biotechnology and Applied Biochemistry, 2004A pulmonary surfactant reduces surface tension at the air/liquid interface of the alveoli and stabilizes alveoli at low lung volumes. Surfactant deficiency and dysfunction were shown to be present in a number of pulmonary diseases, and surfactant replacement therapy is the common clinical conduct.
Flávia Saldanha Kubrusly +3 more
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The Pulmonary Surfactant System
Physiology, 1994The pulmonary surfactant system includes specific proteins involved in the regulation of surfactant secretion and recycling, conversion of secreted lamellar bodies to tubular myelin, film adsorption, and stimulation of alveolar macrophages. Hydrophobic proteins are essential for the rapid physiological action of exogenous surfactants currently used in
Lmg van Golde +2 more
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Effect of Pulmonary Pathogens on Surfactant
Diseases of the Chest, 1968SUMMARY A crude preparation of pulmonary surfactant was obtained from rabbit lungs by lavage of the broncho-alveolar space. Lyophilized and reconstituted solutions of surfactant were incubated with various pure strains of bacteria. Some bacteria reduced surface tension during incubation, these were P. aeruginosa, A.
Myron Rose +2 more
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Pulmonary Surfactant and Evolution of the Lungs
Science, 1970Pulmonary surfactant has been looked for and found in 11 representatives of four vertebrate classes. The amount of surfactant, estimated by quantitative spreading as a surface film, correlates well with alveolar surface area and with the amount of saturated, mainly dipalmitoyl, phosphatidylcholine in the lung parenchyma.
John A. Clements +2 more
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Surfactant in Pulmonary Disease
New England Journal of Medicine, 1965THOUGH Neergaard pointed out thirty-five years ago1 that the properties of pulmonary alveolar surfaces must influence the function of the lungs and Macklin2 suggested more than ten years ago that certain alveolar epithelial cells may regulate these properties, their proposals received little attention. More recently it was deduced3 from the behavior of
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Ventilation and secretion of pulmonary surfactant
The Clinical Investigator, 1992Various factors are involved in the regulation of surfactant secretion: chemical agonist; local environmental factors such as mediators, locally produced hormones, and possibly pH; and finally, mechanical stress occurring during lung inflation. Here we suggest a model of regulation which is grouped into three levels: a basal autoregulatory mechanism ...
H. Wirtz, Marc Schmidt
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Smoking and Pulmonary Surfactant
New England Journal of Medicine, 1972Elsewhere in this issue of the Journal Finley and Ladman report further intriguing observations on the material obtained by regional lavage from the lungs of healthy young cigarette smokers and non...
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