Results 151 to 160 of about 1,111,710 (304)

Antiseizure potency and neurotoxicity of the enantiomers of fenfluramine and norfenfluramine in rats and correlations with their concentrations in plasma and brain

Epilepsia, EarlyView.
Abstract Objective Based on the evidence that fenfluramine‐induced anorexia, weight loss, and cardiovascular toxicity are primarily mediated by the d‐enantiomers of fenfluramine and its metabolite norfenfluramine, we investigated pharmacokinetic/pharmacodynamic correlations for the active enantiomers of fenfluramine and norfenfluramine in the rat ...
Yara Sheeni, Dinorah Barasch, Tawfeeq Shekh‐Ahmad, Emilio Perucca, Meir Bialer   +4 more
wiley   +1 more source

Fenfluramine in Rett syndrome: A multidimensional clinical study

Epilepsia Open, EarlyView.
Abstract Objective Rett syndrome (RTT) is a severe neurodevelopmental disorder frequently associated with drug‐resistant epilepsy, autonomic dysfunction, respiratory abnormalities, sleep disturbances, and behavioral impairment. Fenfluramine has shown efficacy in developmental and epileptic encephalopathies and may provide broader therapeutic benefits ...
Elena Gonzalez‐Alguacil, Nuria Lamagrande Casanova, Manuel Luján Bonete, David Mansilla Lozano, Juan José García Peñas, María Ballará Petitbó, Rocío Trincado Lamuño, Verónica Cantarín‐Extremera, Raquel Díaz Conejo, César Rodríguez Sánchez, Adrián García Ron, Víctor Soto Insuga   +11 more
wiley   +1 more source

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai, Hirohiko Aikawa, Yoshiaki Morita, Keiko Ohta‐Ogo, Teruo Noguchi   +4 more
wiley   +1 more source

Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care

Epilepsia Open, EarlyView.
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley, Peter Widdess‐Walsh, Christine Linehan, Danielle M. Andrade, Norman Delanty, Patrick B. Moloney   +5 more
wiley   +1 more source

Effects of flow‐controlled expiration on oxygenation and early recovery in horses undergoing general anaesthesia

Equine Veterinary Journal, EarlyView.
Abstract Background FLow‐controlled EXpiration (FLEX) has been shown to significantly enhance oxygenation in horses under clinical and experimental conditions. Objectives To compare pulmonary gas exchange during early recovery following general anaesthesia in horses ventilated with FLEX compared with conventional intermittent positive pressure ...
Allison Mika, Jerrianne Brandly, Alycia Frampton, Hope Douglas, Miranda Starr, Henry Benchimol, Klaus Hopster   +6 more
wiley   +1 more source

Long-Term Pulmonary Valve Function After the Ross Procedure

, 2019
Long-Term Pulmonary Valve Function After the Ross ...
L Grigg (13706023), P Skillington (13593895), Rochelle Wynne (13091535), E Buratto (13606078), M Larobina (13606084), T Fricke (19228099)   +5 more
core  

Pulsed wave tissue Doppler imaging of the left ventricle in foals: Feasibility, inter‐ and intra‐observer variability and wave pattern over the first days of life

Equine Veterinary Journal, EarlyView.
Abstract Background Tissue Doppler imaging (TDI) may improve the assessment of myocardial function in neonatal foals. Objectives To document the feasibility of left ventricular pulsed wave (PW) TDI, inter‐ and intra‐observer variability and wave pattern over the first 5 days of life. Study Design Prospective observational study.
Fernanda Timbó D'el Rey Dantas, Gayle Hallowell, Carolina Castagnetti, Giovanni Romito, Laura Menchetti, Aurora Mannini, Aliai Lanci, Jole Mariella, Francesca Freccero   +8 more
wiley   +1 more source

Intravascular Ultrasound Guidance for Transcatheter Pulmonary Valve Replacement: A Feasibility Study. [PDF]

JACC Adv
Sadowski KA, Kania M, Stark W, Woźniak O, Kobari Y, Kądziela J, Mintz GS, De Backer O, Demkow M, Kalińczuk Ł.   +9 more
europepmc   +1 more source

Oral Bacterial Extracellular Vesicles as Systemic Messengers: A Mouth–Gut–Systemic Axis Paradigm

Gut Medicine, EarlyView.
ABSTRACT Oral microbiome dysbiosis not only associated with localized periodontal disease but also with multiple systemic diseases, including cardiovascular disease, diabetes mellitus, Alzheimer's disease, rheumatoid arthritis, and cancer. However, the efficiency with which intact viable bacteria cross biological barriers to reach distant organs is ...
Yaping Huang, Narisu Hu, Shuang Pan, Sohaib Shujaat, Zhihui Tang, Hongyang Ma   +5 more
wiley   +1 more source

Effects of pulmonary balloon valvuloplasty on right coronary artery blood flow in pulmonary valve stenosis

, 1998
Pulmonary balloon valvuloplasty results in improvement in the right coronary artery blood flow velocity pattern and the volumetric flow in patients with pulmonary valve stenosis.
Kallikazaros, IE, Toutouzas, PK, Stefanadis, CI, Tsioufis, CP, Stratos, CG   +4 more
core   +1 more source