Results 201 to 210 of about 134,847 (264)

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Hybrid Pulmonary Valve Replacement in Very Large Right Ventricular Outflow Tract Using a Self-Expanding Valve. [PDF]

JACC Case Rep
Schaffner D, Cho MY, Kleine-Brueggeney M, Berger F, Kramer P.   +4 more
europepmc   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Percutaneous vegetation debulking and right ventricular assist device support as a bridge to surgery for transcatheter pulmonary valve endocarditis. [PDF]

JTCVS Tech
Frankel WC, Paul A, Karamlou T, Das TM, Costello JP, Najm HK, Ghobrial J.   +6 more
europepmc   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Hypoattenuating Leaflet Thickening After Transcatheter Pulmonary Valve Implantation: An Urgent Call to Action. [PDF]

JACC Case Rep
Spagnolo P, Bevilacqua F, Perillo N, d'Aiello AF, Guglielmi G, Pasqualin G, Micheletti A, Negura DG, Chessa M.   +8 more
europepmc   +1 more source

Intravascular Lithotripsy to Facilitate Extraction of Very Old Cardiac Implantable Electronic Devices Leads

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background One of the challenges encountered when extracting transvenous leads with long dwell times is the presence of dense calcifications encasing the leads. This is the most likely reason for failure to advance a laser extraction sheath.
Jamie Kowal, Travis Richardson, George H. Crossley   +2 more
wiley   +1 more source

Progress With New Challenges: Self-Expanding Transcatheter Pulmonary Valve Endocarditis. [PDF]

JACC Case Rep
Gregg D, Kendsersky P, Gaydos SS, Rhodes JF, Kavarana MN, Felmly LM.   +5 more
europepmc   +1 more source

Sustained Idiopathic Outflow Tract Ventricular Tachycardia: Clinical Evidence for RVOT Predominance

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Idiopathic outflow tract premature ventricular contractions (PVCs) are most commonly localized in the right ventricular outflow tract (RVOT). The clinical significance of sustained outflow tract ventricular tachycardia (OT‐VT) regarding any predominance to one specific anatomic area remains uncertain.
Moneeb Khalaph, Nadica Trajkovska, Maxim Didenko, Mustapha El Hamriti, Guram Imnadze, Denise Guckel, Philipp Lucas, Martin Braun, Thomas Fink, Vanessa Sciacca, Ersan Akkaya, Sebastian E. Beyer, Hassan El‐Shirbiny, Maximilian Mörsdorf, Christian Sohns, Philipp Sommer, Angeliki Darma   +16 more
wiley   +1 more source