Results 91 to 100 of about 104,507 (267)

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Pulmonary valve balloon valvuloplasty compared across three age groups of children

International Journal of General Medicine, 2012
Shamsi Ghaffari,1 Mohammed Reza Ghaffari,2 Ali Reza Ghaffari,3 Somaie Sagafy11Department of Pediatric Cardiology, Cardiovascular Research Center, 2Department of Tuberculosis and Lung Research, 3Department of Internal Medicine, Tabriz University of ...
Ghaffari S, Ghaffari MR, Ghaffari AR, Sagafy S   +3 more
doaj  

Early Use of Fentanyl Increases Risk of Delirium in Patients Transfer to the intensive Care Unit After Cardiac Surgery Immediately: A Target Trial Emulation

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Aim In the post‐operative period of cardiac surgeries, the majority of patients are admitted to the intensive care unit (ICU) for ongoing management, where delirium frequently occurs as a complication. However, the association between various analgesic regimens and the onset of postoperative delirium in ICU patients following cardiac surgery ...
Zhongkai Qu, Weisheng Chen, Xinya Li, Bo Chen, Li Li, Shuna Li, Liying Huang, Ningxia He, Jun Lyu, Zhigang Wang   +9 more
wiley   +1 more source

Reversal of echocardiographic right-sided heart pathology in a dog with severe pulmonary hypertension: a case report

Veterinary Medicine: Research and Reports, 2015
Peggy McMahon,1 Carley Saelinger 2  1Emergency and Critical Care Department, 2Cardiology Department, Animal Specialty and Emergency Center, Los Angeles, CA, USA Abstract: Pathologic right-sided heart changes are a common echocardiographic ...
McMahon P, Saelinger C
doaj  

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

Macroscopical and histological characterization of the perineal membrane and deep perineal pouch

Journal of Anatomy, EarlyView.
The existence of the deep transverse perineal muscle remains controversial. While the macroscopic appearance of the tissue in the deep perineal pouch differs between men and women, the differences in the histological composition of this fibromuscular plate is still unclear.
Morten Kampelmann, Carina Grindley, Christian Mühlfeld, Andreas Schmiedl   +3 more
wiley   +1 more source

Association Between Perioperative Sleep Disorders and Post‐Operative Delirium in Cardiac Surgeries: A Systematic Review and Meta‐Analysis

Journal of Sleep Research, EarlyView.
Overview of studies included in the systematic review investigating the association between perioperative sleep disorders (PSD) and postoperative delirium (POD) in patients undergoing cardiac surgery. ABSTRACT Post‐operative delirium (POD) is an acute deterioration in cognitive function and highly prevalent after cardiac surgery (CS; up to 55 ...
Hesam Varpaei, Pallav Deka, Lorraine B. Robbins, Kousha Farhadi, Mathew Reeves, Fabrice Mowbray, Stuart F. Quan   +6 more
wiley   +1 more source

ALCAPA Presents in an Adult with Exercise Intolerance but Preserved Cardiac Function

Case Reports in Cardiology, 2012
Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly that usually manifests as severe left-sided heart failure and mitral valve insufficiency during the first one to two months of life. The majority
Yan Liu, Beth W. Miller
doaj   +1 more source

Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The pharmacokinetics of sildenafil are ill‐defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client‐owned dogs with
Mariko Yata, Teresa C. DeFrancesco, John D. Bonagura, Mark G. Papich   +3 more
wiley   +1 more source