Results 171 to 180 of about 1,817,394 (413)

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

open access: yesAdvanced Science, EarlyView.
The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou   +11 more
wiley   +1 more source

Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
A novel structure‐function relationship is identified for lung‐targeting ionizable lipids with nonpermanent charges. These lipids feature N‐methyl and secondary amine groups in their heads and three tails derived from epoxyalkanes, demonstrating superior pulmonary selectivity and efficiency.
Xiaoyan He   +9 more
wiley   +1 more source

Self-adaptive vision-language model for 3D segmentation of pulmonary artery and vein [PDF]

open access: yesarXiv
Accurate segmentation of pulmonary structures iscrucial in clinical diagnosis, disease study, and treatment planning. Significant progress has been made in deep learning-based segmentation techniques, but most require much labeled data for training. Consequently, developing precise segmentation methods that demand fewer labeled datasets is paramount in
arxiv  

Pulmonary Vein Isolation using a High Density Mesh Ablator Catheter: Incorporation of three-Dimensional Navigation and Mappin [PDF]

open access: yes, 2009
Background: We evaluated the use of a novel High Density Mesh Ablator (HDMA) catheter in combination with three-dimensional navigation for the treatment of paroxysmal atrial fibrillation.
André Ng, G.   +6 more
core   +1 more source

Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury

open access: yesAdvanced Science, Volume 12, Issue 16, April 24, 2025.
A biomimetic MOF nanocarrier for macrophage‐targeting delivery of both mitochondria and anti‐miR‐127 is designed with an aim to revitalize macrophages and remold the inflammatory microenvironment for treating acute lung injury. By leveraging the macrophages‐targeting property and pH‐responsiveness, ZIF‐8 nanocarriers facilitated efficient delivery of ...
Xin Shou   +10 more
wiley   +1 more source

Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation

open access: yesAdvanced Science, EarlyView.
Annexin A3 (ANXA3) plays an endogenous protective role in endothelial dysfunction in sepsis by stabilizing the actin cytoskeleton, modulating cell permeability, and inhibiting pATF2/CD62E inflammatory signaling. Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis.
Manyu Xing   +4 more
wiley   +1 more source

Video assisted thorascopic assisted correction of left partial anomalous pulmonary venous connection: one case report

open access: yesJournal of Cardiothoracic Surgery
Introduction The left partial anomalous pulmonary vein connection is a rare congenital heart disease, especially with intact atrial septum. Now we reported a case of the left superior pulmonary vein drainage to left innominate vein through a vertical ...
Gengxu He   +6 more
doaj   +1 more source

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