Results 81 to 90 of about 1,417,297 (301)

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Left atrial appendage (LAA) electrical isolation by Maze‐like catheter substrate modification in presence of LAA‐occluder device: A case report

Clinical Case Reports, 2020
Maze‐like linear substrate modification in atrial fibrillation patients nonresponders to pulmonary vein isolation represents a feasible technique to gain left atrial appendage electrical isolation even in the presence of a Watchman occluder device.
Simone Zanchi, Lorenzo Bianchini, Stefano Bordignon, Fabrizio Bologna, Shota Tohoku, Shaojie Chen, Julian K. R. Chun, Boris Schmidt   +7 more
doaj   +1 more source

A randomized comparison of cryoballoon versus duty-cycled multielectrode radiofrequency ablation for pulmonary vein isolation

, 2014
Cryoballoon (CB) and multipolar phased radiofrequency (RF) ablation with the Pulmonary Vein Ablation Catheter (PVAC) have been introduced as a faster and simpler procedure for pulmonary vein isolation (PVI).
Lenz, Anna Christina
core  

Unmasking the dormant pulmonary vein conduction with adenosine administration after pulmonary vein isolation with laser energy

, 2015
The isolation of the pulmonary veins (PVs) is the mainstay of atrial fibrillation (AF) ablation, which with current ablation techniques can be achieved in almost all cases.
Riegger, Günter, Maier, Lars Siegfried, Üçer, Ekrem, Debl, Kurt, Jungbauer, Carsten Gerald, Seegers, Joachim, Fredersdorf, Sabine   +6 more
core   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Pulmonary vein isolation in the treatment of atrial fibrillation

, 2016
Saurabh Kumar, Gregory F Michaud Cardiac Arrhythmia Service, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA Abstract: Atrial fibrillation (AF) is the commonest arrhythmia in humans and is associated with marked reduction in ...
Michaud GF, Kumar S
core  

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Recent advances in rhythm control for atrial fibrillation [version 1; referees: 2 approved]

F1000Research, 2017
Atrial fibrillation (AF) remains a difficult management problem. The restoration and maintenance of sinus rhythm—rhythm control therapy—can markedly improve symptoms and haemodynamics for patients who have paroxysmal or persistent AF, but some patients ...
Richard Bond, Brian Olshansky, Paulus Kirchhof   +2 more
doaj   +1 more source

Renal denervation: can we press the “ON” button again in 2020?

Advances in Interventional Cardiology, 2020
In December 2018, an article summarizing available results of randomized studies on renal denervation (RDN), entitled “Renal denervation: can we press the ON button again?” was published in the Advances in Interventional Cardiology.
Jacek Kądziela, Ewa Warchoł-Celińska, Aleksander Prejbisz, Andrzej Januszewicz, Adam Witkowski, Konstantinos Tsioufis   +5 more
doaj   +1 more source

A case of unidirectional exit block during pulmonary vein isolation

, 2017
: We present a case of unidirectional exit block from a pulmonary vein (PV) during a pulmonary vein isolation procedure. Following circumferential antral applications around the right PVs, PV pacing showed capture without exit.
Sandorfi, Gabor, Gabor Sandorfi, Bories, Wim, Andrea Sarkozy, Heidb\ufcchel, Hein, Wim Bories, Sarkozy, Andrea, Hein Heidbuchel   +7 more
core   +1 more source