Results 151 to 160 of about 694,632 (248)

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

A Custom Annotated Dataset for Segmentation of Pulmonary Veins, Arteries, and Airways. [PDF]

Sci Data
Liu J, Zhang Z, Niu B, Kang S, Ren J, Wang L, Xu K.   +6 more
europepmc   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Stenosis of the left pulmonary veins after atrial fibrillation catheter ablation. [PDF]

Einstein (Sao Paulo), 2023
Estruzani T, Mitsutake LKN, Alexandre B, Ishikawa WY, Sasdelli Neto R, Szarf G, Silva MMA, Funari MBG, Paul LC, Fonseca EKUN.   +9 more
europepmc   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Beyond the Pulmonary Veins: The Influence of Pulsed Field Ablation on the Superior Vena Cava. [PDF]

J Arrhythm
Yoshida E, Sakamoto Y, Osanai H, Asano H.   +3 more
europepmc   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Short‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter propensity score‐matched study of 3213 patients compared intracorporeal (IA) and extracorporeal (EA) anastomosis during minimally invasive colectomy. IA was associated with a significantly lower incidence of intraoperative blood loss ≥ 200 mL (2.5% vs.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Kae Okoshi, Yasunori Deguchi, Keiji Nagata, Tomoaki Okada, Rei Mizuno, Kazutaka Obama   +9 more
wiley   +1 more source

Pulmonary Veins, Posterior Wall, and Non-Pulmonary Vein Trigger Ablation in Persistent Atrial Fibrillation and Dextrocardia. [PDF]

JACC Case Rep
Scacciavillani R, Perna F, Comerci G, Pelargonio G.   +3 more
europepmc   +1 more source

Radical Resection of the Third Portion of the Duodenum for Secondary Aortoduodenal Fistula

Annals of Gastroenterological Surgery, EarlyView.
Secondary aortoduodenal fistula most commonly involves the third portion of the duodenum and requires definitive management of both vascular and gastrointestinal components. We demonstrate a step‐by‐step technique for radical duodenal resection and reconstruction performed in structured collaboration with cardiovascular surgeons.
Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tatsuichiro Seto, Yuji Soejima   +4 more
wiley   +1 more source

Catheter Ablation for Persistent Atrial Fibrillation: Rationale, Evidence, and Contemporary Strategies Beyond Pulmonary Veins. [PDF]

J Clin Med
Ruscio E, Marsilia M, Bencardino G, Narducci ML, Perna F, Comerci G, Pinnacchio G, Burzotta F, Scacciavillani R, Pelargonio G.   +9 more
europepmc   +1 more source