Results 11 to 20 of about 304 (69)
Advanced Science, EarlyView.USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian +9 more
wiley +1 more source
Neutrino Oscillation in a Minimal Length Spacetime
Astronomische Nachrichten, EarlyView.ABSTRACT We investigate how neutrino oscillations are modified in a non‐commutative spacetime characterized by a minimal length scale, described by the Quesne–Tkachuk algebra. By incorporating the algebra's deformation parameter β$$ \beta $$ into the effective neutrino mass, we derive the two‐flavor oscillation probability in this non‐commutative ...
Luísa Nadal‐Camargo +3 more
wiley +1 more source
The absence of women's scientific contributions in core UK pre‐university science qualifications
British Educational Research Journal, EarlyView.Abstract Despite their groundbreaking contributions to our understanding of the natural world and the universe, women's roles in biology, chemistry, physics, astronomy, environmental science and geology remain largely absent from standard educational specifications in the United Kingdom (UK), particularly at Key Stage 4 (KS4) and Key Stage 5 (KS5), or ...
G. J. Cooke +7 more
wiley +1 more source
Deep Underground Science and Engineering, EarlyView.This study demonstrates that the ultra‐low background radiation environment in deep underground laboratories significantly inhibits the proliferation of both normal nasopharyngeal epithelial cells (HNEPC) and nasopharyngeal carcinoma cells (HNE‐1) cells, with malignant cells exhibiting higher sensitivity.
Yuhao Zou +15 more
wiley +1 more source
Multi‐omics–driven precision medicine
iMeta, EarlyView.Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li +20 more
wiley +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To evaluate real‐world safety experience with aflibercept 8 mg in a large case series of patients with neovascular age‐related macular degeneration (nAMD). Methods Due to a high proportion of patients on short treatment intervals, patients with nAMD at a Danish tertiary retina clinic were systematically switched to aflibercept 8 mg ...
Mary Graciya Karunainathan +12 more
wiley +1 more source
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Canine cancer imposes substantial emotional, financial and decisional burden on owners navigating complex referral pathways and treatment options. Understanding how owners experience and interpret these pathways is essential to improving care delivery.
Georgina Anne Tarrant +5 more
wiley +1 more source
MedComm, Volume 7, Issue 11, November 2026.This 16‑week study assessed impact of dupilumab on skin barrier function in patients with moderate‑to‑severe atopic dermatitis (AD). Tape‑stripped stratum corneum samples for multi‑omic profiling, alongside transepidermal water loss measurements, were collected from lesional/non‑lesional AD skin and healthy controls at seven time points.
Taoming Liu +21 more
wiley +1 more source
New Phytologist, Volume 252, Issue 4, Page 1602-1619, November 2026.Overview of the experimental design and 13CO2 pulse‐labeling approach in the field. Summary Despite its relevance for plant nutrient acquisition, the role of the hyphosphere in structuring fungal–bacterial networks and mediating carbon–nitrogen (C–N) exchange under field conditions remains unclear.
Luise Brandt +7 more
wiley +1 more source