ChemistryOpen, EarlyView.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
Successful Bentall Surgery in a Moyamoya Disease Patient with Intraoperative Brain Protection via IABP-Induced Pulsatile Flow and CO<sub>2</sub> Management during Cardiopulmonary Bypass. [PDF]
Surg Case RepHanda K +7 more
europepmc +1 more source
Optimised passive marker device visibility and automatic marker detection for 3-T MRI-guided endovascular interventions: a pulsatile flow phantom study. [PDF]
Eur Radiol Exp, 2022 Nijsink H +6 more
europepmc +1 more source
Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)
Phytotherapy Research, EarlyView.ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley +1 more source
How I do it: simple ad-hoc pulsatile pump model for realistic microsurgical training under pulsatile flow. [PDF]
Acta Neurochir (Wien)Parvin R +6 more
europepmc +1 more source
Small Methods, EarlyView.A particle‐resolved method for porosity and surface area analysis of microparticles is presented, based on single‐particle trajectory tracking via optical video microscopy integrated with microfluidics and LED illumination. Operating with minimal analyte and no drying steps, the approach offers per‐particle analysis using widely available laboratory ...
Fabian Rohne +9 more
wiley +1 more source
Influence of PEG Molecular Weight on Washout Resistance and Deposition Efficiency of Magnetoresponsive Nanoclusters Under Pulsatile Flow for Magnetic Drug Targeting. [PDF]
Pharmaceuticals (Basel)Bernad SI, Bernad ES.
europepmc +1 more source
Portable Radar for Noncontact Heart Rate Monitoring and Estrus Detection in Dairy Cows
IEEJ Transactions on Electrical and Electronic Engineering, EarlyView.This study introduces a portable radar system for real‐time monitoring of respiratory and heart rates in dairy cows. It uses millimeter‐wave Frequency Modulated Continuous Wave (FMCW) radar to perform noncontact physiological sensing, reducing behavioral disturbance. The radar system's design prioritizes portability, cost‐effectiveness, and robustness,
Yingxiu Li +7 more
wiley +1 more source
Comparison of pulsatile flow dynamics before and after endovascular intervention in 3D-printed patient-specific internal carotid artery aneurysm models using 1000 fps photon-counting detectors for Simultaneous Biplane High Speed Angiography (SB-HSA). [PDF]
Proc SPIE Int Soc Opt Eng, 2023 Wu XS +6 more
europepmc +1 more source
Using programmable infusion pump in avian species – a validation methodology in geese
Wildlife Biology, EarlyView.Wildlife face anthropogenic and natural stressors that affect their physiology and behaviour. The activity of the hypothalamic–pituitary–adrenal axis and glucocorticoid (GC) production is intrinsically linked with energy regulation and environmental stressors.
Myriam Trottier‐Paquet +5 more
wiley +1 more source