Results 141 to 150 of about 4,106,222 (239)

Mechanical pressure on endothelial cells mediates remote ischaemic preconditioning‐induced neuroprotection via miR‐126

Experimental Physiology, EarlyView.
Abstract Remote ischaemic preconditioning (RIPC) uses brief limb ischaemia to protect distant organs, but the mechanism of travel of the protective signal remains unclear. This study investigated whether endothelial cells (ECs) contribute to RIPC‐induced neuroprotection and the underlying mechanisms.
Xiaojie Wang, Lei Yan, Hongwei Zhu, Yifan Li, Qi Liu, Wei Li, Kerui Gong, Zhijun Zhao, Chunyang Zhang, Gang Fu, Guo Shao, Xunming Ji   +11 more
wiley   +1 more source

Brain tissue pulsation responses to a low‐level expiratory resistance manoeuvre: A pilot healthy volunteer study

Experimental Physiology, EarlyView.
Abstract Pulsatility of the brain has been hypothesised to be linked to intracranial pressure (ICP), although the nature of this relationship remains poorly understood. We used a low‐level expiratory resistance manoeuvre to characterise brain tissue pulsation (BTP) responses in a pilot healthy volunteer study.
Jennifer K. Nicholls, Emma M. L. Chung, Jonathan Ince, Edward Pallett, Jatinder S. Minhas, Andrea Lecchini‐Visintini   +5 more
wiley   +1 more source

The acute effects of exercise intensity and inorganic nitrate supplementation on the Buckberg ratio in postmenopausal females

Experimental Physiology, EarlyView.
Abstract Menopause increases coronary heart disease risk, in part through reduced oestrogen‐mediated nitric oxide (NO) bioavailability. The Buckberg ratio, an index of myocardial oxygen supply–demand balance, in which higher values reflect more favourable myocardial perfusion, is lower in postmenopausal females (PMFs) than in age‐matched males.
Cassandra C. Derella, Austin C. Hogwood, Joaquin Ortiz de Zevallos, Nathan R. Weeldreyer, Kaitlin M. Love, Arthur Weltman, Jason D. Allen   +6 more
wiley   +1 more source

The pulsatility index and the resistive index in renal arteries in patients with hypertension and chronic renal failure

, 1995
The pulsatility index (PI) and the resistive index (RI) are used as pulsed-wave Doppler measurement of downstream renal artery resistance. Little information is available on their value in chronic renal failure and their correlation to parameters of ...
Petersen, J R, Ladefoged, S D, Jensen, H A, Mehlsen, J, Petersen, L J   +4 more
core   +1 more source

Resistance‐trained young men exhibit enhanced carotid vasoreactivity during the cold pressor test

Experimental Physiology, EarlyView.
Abstract The function of the common carotid artery (CCA) is integral to the regulation of cerebral perfusion. Although endurance training is associated with consistent vascular benefits, the effects of resistance training on CCA function are unclear.
Ian Hornby‐Foster, Cory T. Richards, Aimee L. Drane, Freya M. Lodge, Michael Stembridge, Rachel Lord, Zaheer Yousef, Keeron Stone, Barry J. McDonnell, Christopher J. A. Pugh   +9 more
wiley   +1 more source

Increasing paced heart rate reduces cerebral pulsatility

Experimental Physiology, EarlyView.
Abstract Cerebral pulsatility is a key index of cerebral haemodynamics, a central determinant of intravascular shear stress within intracranial vessels, and is associated with cerebral small vessel disease. It increases with a spontaneously falling heart rate, but the effect of altering heart rates on cerebral haemodynamics is unknown.
A. J. S. Webb, J. Thomas, O. Llwyd, N. Herring   +3 more
wiley   +1 more source

High‐altitude headache: Insights into pathophysiology and potential treatment implications

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla, Florian Frank, Giacomo Strapazzon, Justin Lawley   +3 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Clustering of Cerebral Microbleeds in Cerebral Amyloid Angiopathy: A Flow Territory‐Based Analysis

Journal of Magnetic Resonance Imaging, Volume 64, Issue 5, Page 1241-1249, November 2026.
ABSTRACT Background Cerebral microbleeds (CMBs) are a key imaging marker of cerebral amyloid angiopathy (CAA), but their individual spatial distribution and potential clustering remain poorly understood. Purpose This study assessed whether CMBs exhibit patient‐specific, flow territory‐based clustering in sporadic (sCAA) and Dutch‐type hereditary CAA (D‐
Manon R. Schipper, Reinier G. J. van der Zwet, Jelle J. Goeman, Thijs W. van Harten, Emma A. Koemans, Marieke J. H. Wermer, Marianne A. A. van Walderveen, Matthias J. P. van Osch   +7 more
wiley   +1 more source

Flow 2.0: A Standardized Toolbox for Real‐Time Phase‐Contrast MRI of Neurofluid Dynamics

Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2092-2105, November 2026.
ABSTRACT Purpose Real‐time phase‐contrast MRI (RT‐PC) enables continuous quantification of physiological flow dynamics across multiple temporal frequencies, but its broader application is limited by complex and fragmented post‐processing workflows.
Pan Liu, Olivier Balédent
wiley   +1 more source