Results 51 to 60 of about 501 (275)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

LINEAR PULSATION CHARACTERISTICS OF MIRA VARIABLE STARS

Journal of Sciences, Islamic Republic of Iran, 2003
The linear adiabatic pulsation-periods of Mira variable stars have been derived. Approximately 2701[1]models were calculated for M = 0.7 MΘ to 2 MΘ stars with radii from 180 RΘ to 340 RΘ and luminosities from 2800 LΘ to 10,000 LΘ. The chemical composition of all models is (X,Z) = (0.7,0.02). From the result of this study, linear relations on Luminosity-
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Observational Properties of β Cephei Stars: 88 New Samples Discovered Based on TESS and Gaia Data

The Astrophysical Journal Supplement Series
We present a systematic investigation of β Cephei (BCEP) stars by integrating photometric data from the Transiting Exoplanet Survey Satellite (TESS) with astrometric parameters from Gaia Data Release 3.
Xiang-dong Shi, Sheng-bang Qian, Li-ying Zhu, Lin-jia Li, Er-gang Zhao, David Mkrtichian, Farkhodjon Khamrakulov, Wen-xu Lin   +7 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Variable Blue Straggler Stars in the Open Cluster NGC 6819 Observed in the Kepler “Superstamp” Field

The Astronomical Journal, 2023
NGC 6819 is an open cluster of age 2.4 Gyr that was in the NASA Kepler spacecraft’s field of view from 2009 to 2013. The central part of the cluster was observed in a 200 × 200 pixel “superstamp” during these four years in 30 minute cadence photometry ...
Joyce A. Guzik, Andrzej S. Baran, Sachu Sanjayan, Péter Németh, Anne M. Hedlund, Jason Jackiewicz, Lori R. Dauelsberg   +6 more
doaj   +1 more source

Chaos in variable stars: Topological analysis of W Vir model pulsations [PDF]

Chaos: An Interdisciplinary Journal of Nonlinear Science, 1996
The topological characterization of chaos is applied to the irregular pulsations of a model for a star of the W Virginis type, computed with a state-of-the-art numerical hydrodynamical code. The banded W Vir attractor is found to possess an additional twist when compared to the Rössler band.
Letellier, Christophe, Gouesbet, G., Soufi, F., Buchler, J.R., Kolláth, Z.   +4 more
openaire   +5 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source